Cover Image: March 2013 Scientific American Magazine See Inside

Could Monkeypox Take Over Where Smallpox Left Off? [Preview]

Smallpox may be gone, but its viral cousins—monkeypox and cowpox—are staging a comeback















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ANCIENT SCOURGE: Smallpox scarred this child for life in 1915.

Image: CORBIS

In Brief

  • When smallpox was eradicated 35 years ago, people stopped getting vaccinated against it.
  • In the intervening years the general population has lost immunity not only to smallpox but also to other poxviruses that were formerly held in check by the smallpox vaccine.
  • The number of cases of monkeypox and cowpox has started to climb, raising the possibility of a new global scourge spreading in smallpox's place.

Ten thousand years ago, when smallpox first emerged, humankind could do little more than pray to the gods for succor. Later known as variola, the virus that caused the disease first attacked the linings of the nose or throat, spreading throughout the body until a characteristic rash followed by virus-filled blisters developed on the skin. Over the course of recorded history, the “speckled monster” killed up to a third of the people it infected. During the 20th century alone, it felled more than 300 million men, women and children.

By the late 1970s, however, the deadly scourge had been eliminated from the face of the earth thanks to mass vaccination campaigns that protected millions and left them with a small scar on their upper arm. With nowhere to hide in the natural world—humans are the virus's only host—variola was beaten into extinction. Today the only known viral samples are locked in two specialized government laboratories, one in the U.S. and the other in Russia. Absent a catastrophic lab accident, deliberate release or the genetic reengineering of the virus, smallpox will never again spread death and misery across the globe.


This article was originally published with the title New Threat from Poxviruses.



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4 Comments

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  1. 1. rigg38a 03:14 AM 3/6/13

    Absent a catastrophic lab accident, deliberate release or the genetic reengineering of the virus, smallpox will never again spread death and misery across the globe.Since when has "absent" been other than an adjective? It this creeping language and grammar violation?

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  2. 2. Casual Reader 12:11 PM 3/6/13

    If you look up 'absent' - it is a verb or adjective or preposition. Duh.

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  3. 3. bucketofsquid 01:37 PM 3/11/13

    Cowpox and monkeypox are a lot less deadly than smallpox. I'll take my chances with the lesser poxes unless they get really common.

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  4. 4. gkile0534 in reply to rigg38a 07:41 PM 3/26/13

    Not true. The generation born before the 1970's were all inoculated with the vaccine for smallpox, also the military. After that no one has been inoculated for it. Therefore, if a biological threat was issued of smallpox then it can become active as you see in this article or a less viral agent of it. And there are still tubes of smallpox in the hands of the WHO locked up.

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