A few weeks ago a clinic in Mumbai claimed to have identified a dozen patients with a strain of tuberculosis (TB) resistant to all known treatments. TB is a highly contagious lung infection that kills about 1.5 million people each year worldwide, according to the World Health Organization (WHO), so the development of a totally untreatable form of the disease would be cause for alarm. "It conveys that there is no hope, that not a single drug works," says Madhukar Pai, a tuberculosis researcher at McGill University in Montreal.

Fortunately, it does not appear that the Mumbai cases are completely untreatable. After evaluating the cases last week, India's Ministry of Health and Family Welfare reported that the patients actually had "extensively drug-resistant" tuberculosis, a form of the disease that is difficult to treat, but not incurable. Although three of the 12 patients have died, the other nine are reportedly being treated with antibiotics used to treat extensively drug-resistant TB, such as clofazimine and rifabutin.

Still, the case has prompted WHO to schedule a meeting in March to discuss the merits of creating a new "totally drug-resistant” category of tuberculosis. Most likely, "extensively drug-resistant," or XDR, will remain the top level of tuberculosis threat. For one thing, current laboratory tests for determining drug-resistant TB are not reliable enough to rule out all TB drugs conclusively, particularly three of the six classes of second-line drugs. "The tests aren't highly reproducible," says Peter Cegielski, head of the U.S. Centers for Disease Control and Prevention's drug-resistant TB program. "You can even get different results from the same patient specimen."

WHO cannot designate a new disease category without clear, quantifiable diagnostic criteria. For example, XDR-TB is defined as tuberculosis that is resistant to the main first-line TB drugs—rifampin and isoniazid—and to two or more of the second-line drugs for which there are reliable susceptibility tests.

There are also new tuberculosis drugs on the horizon, including two that will likely be available to patients in the next few years, making the timing of adding a "totally drug-resistant" TB category impractical.

That doesn't mean, however, that it is impossible for an untreatable form of TB to exist. "It's reasonable to discuss it," Cegielski says. It also does not mean that public health workers can rest easy. Drug-resistant TB remains a huge problem worldwide. Not only does it take months or, in some cases, years to treat, but once drug-resistant strains develop, they can be passed from person to person.

What the recent Indian case really highlights, rather than the potential for total drug-resistance, is the need for consistent tuberculosis management worldwide, says Carole Mitnick, a public health researcher at Harvard University who specializes in the treatment of drug-resistant TB. "It reflects the lack of equal access to quality care and treatment," she says.

For example, tuberculosis medications are highly restricted in some countries, such as Brazil, but are more freely available in others. In India, where there are about two million new TB cases a year, it is possible to get some TB drugs from pharmacies without a prescription, says McGill's Pai, who is from India and has studied TB treatment there. "A lot of patients won't take the full course [of antibiotics], and then they start a new drug. That's the pattern that leads to drug resistance," he says. A study published in PLoS One last year found excessive private market sales of TB drugs in several countries, including India and Indonesia, implying misuse.

5 Comments

1. 1. marynmck 02:15 PM 1/30/12

   Calling Hinduja Hospital a "clinic" without otherwise identifying it casts doubt on its veracity, as if it were a street-front or primary-care clinic — but it's one of the WHO reference labs for India.

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2. 2. tucanofulano 05:46 PM 1/30/12

   Should we be worried that illegal aliens invading and residing in our country bring with them all the plagues and diseases known to mankind, and more ? You bet. The only cure is to actively enforce current laws vigorously 24/7 without any more of the boo-hoo sob stories the left-wing media loves to portray. We take care of murderers, thieves, and other criminals, so why not these criminals ?

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3. 3. alan6302 10:15 PM 1/30/12

   I have seen Indian doctors at work

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4. 4. kgbrown 03:17 PM 2/4/12

   There's no way to seal our borders effectively enough to prevent disease transmission in or out of the country. Supporting WHO DOTS (Direct Observation Treatment Short Course)strategy of control of tuberculosis is the best option, both economically and ethically, read more about the program at http://www.searo.who.int/en/Section10/Section2097/Section2106_10678.htm
   Tuberculosis could easily become a problem again in the US if DOTS-like programs for testing and treating the public don't get the support they need. Without political will, these programs get defunded and public health suffers.

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5. 5. Michael M 05:14 PM 7/10/12

   Somehwere in the range of 8% of US residents test positive for TB. Of these perhaps the same percentage will develop the disease. That will be about 1/2 f one percent of the populace.
   
   Some Asian nations have around 80% of the populace giving positive antibody tests.
   
   Apparently, about 1/3 of humans have been exposed, and TB is the world's second greatest infectious killer, after HIV.
   
   It takes very few TB bacteria to infect, but immune deficiency is a large factor in whether an individual will develop active TB.
   
   Xenophobia and labeling of others as, for instance, liberal, is merely injecting one's personal terror into a discussion, attempting to validate it through thinly disguised (or, rather, undisguised)hate speech.
   
   Such comment is inappropriate for any subject of any concern whatsoever.

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