Fish Oil Supplement Research Remains Murky

Polyunsaturated omega-3 fatty acids are important parts of a healthy diet, but supplement studies have numerous sampling problems















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So, should you take fish oil pills or not? Most researchers agree that oily fish such as salmon and mackerel are far better way to get your fill of good fats. Many of the early, promising studies on omega-3s involved fish rather than fish oil pills (in one, men who were advised to eat fish were 29 percent less likely to die in the two years following a heart attack than men who were not), and a 2010 study by Columbia University scientists reported that following a Mediterranean diet—which, among other things, is rich in fatty fish—reduces the risk of Alzheimer's disease by 34 percent. "Not only may people be benefiting from the omega-3 fatty acids in fish, but the fish may be displacing such foods as hamburgers and quiche from the diet, both high in saturated fat," explains Alice Lichtenstein, director of the Cardiovascular Nutrition Laboratory at Tufts University.

If you don't eat fish, then the question of what to do becomes more difficult. Researchers argue that, ultimately, we need more randomized, controlled clinical trials on omega-3 supplements—particularly in healthy people who don't take medications—but these are becoming rare, in part because the supplements will never be big moneymakers. "Generic fish oil is available, so drug companies don't have any strong motivation to fund trials," Mozaffarian says.

But despite the murky science, if you don't get omega-3s from other sources—or if you have heart disease risk factors but aren't taking medications—omega-3 pills may still be a good idea. "There's no harm in taking a fish oil supplement, and there could be benefits," Mozaffarian says. "The bottom line is that getting some [omega-3] is better than getting none."



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  1. 1. jtdwyer 07:44 AM 9/24/12

    I have anecdotal testimony...
    After many months of (my second round of) chemo administered by my gastrointerologist, including Interferon injections producing severe anemia, my cardiologist independently prescribed Lovaza to treat high triglycerides.

    Knowing nothing about omega-3s, after a week or two my cognitive abilities had been remarkably improved, restored (not knowing they had diminished) to levels I hadn't known for years. Continued use hasn't prevented progressive development of aortic valve stenosis (calcification), but I apparently haven't yet suffered any noticeable dementia...

    Based on my investigations of the remarkable effects I experienced (not knowing what could have possibly been responsible for any improvement in cognitive abilities), I suspect that the (prescription quality) omega-3 supplements had enabled repair of insulated fatty myelin sheaths of neuronal axons previously damaged from severe anemia. For this reason I suggest that anyone suffering from anemia, particularly those undergoing anemia producing chemo therapy, supplement their diet with (at least 1 Gm daily) omega-3.

    I do suggest that medical evaluations of the cognitive abilities of those who have suffered effects of anemia be undertaken. Since my results were very remarkable within 2 weeks, I expect that significant results can be obtained very quickly.

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  2. 2. greenshadow22 12:03 PM 9/24/12

    I was a pack a day smoker for 30 years and I began taking salmon oil in the 90s. I have continued to the present day. I quit smoking in 2008 and I am happy to say that thanks to the fish oil, I have no smokers cough.
    I think that the real benefit to any omega 3 oil is in helping the aging body to maintain moisture in key areas. The lungs, the heart, the eyes especially seem better for me due to taking it. Does the study look at that aspect? I did not see anything about it in your article.

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  3. 3. vapur 03:34 PM 9/24/12

    Purslane is a weed you can pick from your backyard, and has more omega-3 fatty acids than fish oil. All you're doing by buying these 'vitamins' is enriching pharma, the ones trying to eradicate nutritious weeds like dandelions. Foraging: the lost knowledge of an entire generation.

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  4. 4. vapur in reply to greenshadow22 04:17 PM 9/24/12

    Thanks to fish oil you don't have smokers cough? Seriously? When you stop smoking, the cilia in your trachea regrows, helping to push out foreign matter. Correlation != Causation ... those moisture health-and-beauty claims are also suspect.

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  5. 5. jurasketu 09:05 AM 9/25/12

    I've never understand these dumb, largely short-term studies. The THEORY dating back to the 1990s is that the RATIO of Omega-3 to Omega-6 is the key feature. Modern western diets derived literally 40+% of their calories from grain and grain-fed animals and have a bad 3/6 ratio (according to the theory). The fatty acids are key to the building of brain and other body structures which are recycled very slowly once built. Since the body uses Omega-6 if it doesn't have enough Omega-3, the structures still get built - just not as good (allegedly). It would obviously take YEARS of supplementation to reverse/rebuild the affected structures - if EVER. So giving a middle-aged man like myself extra omega-3 might help (Disclaimer: I've always loved and eaten fish AND take a Omega-3 supplement) - I think it is more critical for pregnant women (for the fetus) and children. STUDY THAT PLEASE.

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  6. 6. greenshadow22 in reply to vapur 04:43 PM 9/26/12

    Truly I have no cough. I suppose my lungs are emptying out - I clear my throat now and then - but I have no cough. I tried stopping fish oil and eating a bit more olive oil, I still did not cough, but I lost the capability to wear my contact lenses. Could not keep my eyes moist enough. Floaters increased too. I began taking fish again and the dryness and excessive floaters went away. I am not a doctor or a scientist I can only tell you what my experience has been.

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  7. 7. jstahle 07:38 PM 9/26/12

    "some researchers think that recent negative findings reveal more about us than they do about fish oil."

    Very likely - e.g. that people who take fish oil pills or similar, in general live a more healthy life than the average person. This would easily account for seamingly positive results from fish oil.

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  8. 8. jstahle in reply to greenshadow22 07:50 PM 9/26/12

    greenshadow22

    "thanks to the fish oil, I have no smokers cough."

    Ahrm, when you stop smoking it is common to have a "smoker's cough" for 3 to 6 months. When your lungs have regenerated some it stops, whether you take fish oil, Jelly-O or liquorice.

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  9. 9. wmroche 10:37 PM 9/26/12

    What does alleviate depression is increasing your intake of Vitamin D especially during times of the year when your shadow at noon is longer than your height.

    It is during this time that the UVB rays (that produces vitamin D in the skin) are increasingly blocked by the ozone layer in the upper atmosphere.

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  10. 10. Happy Hal 10:41 PM 9/26/12

    Another fish story, eh?

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  11. 11. sunnystrobe 11:40 AM 9/27/12

    jtdwyer:Re:possible reversal of aortic valve stenosis by diet,
    I would recommend to you the excellent cardiovascular diet concept of Dean Ornish M.D. from Harvard University ( vide under Google).
    As to omega-3 accessibility other than through supplements: Consider to add natural flaxseed , which has the highest omega3 content of any plant food, and can be easily added to breakfast cereals like oats ; just add water to a spoonful, and soak overnight. An easy omega- 3 'designer' muesli recipe is on my website: youthevity.com

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  12. 12. brownale 05:03 PM 9/27/12

    For information about fish oils that has not been biased by industry or big pharma buying the results they want, you should visit the website of the Weston A. Price Foundation.

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  13. 13. timothygreen 11:18 PM 9/27/12

    Omega 3 benefits have been widely discussed around the world where in it was believed that it can greatly help in the body system. Fish oil is enriched with omega 3 fatty acids that can help in making the body healthier. However, there are always controversies on this matter because of different researches coming out around the world.

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  14. 14. omega 06:50 AM 9/28/12

    With over 12,000 clinical studies conducted on fish oil, it is interesting that the verdict is still out.

    I would be very surprised if not pharma paid for this meta analysis. The last two in in 2007 and 2010 was indeed paid for by pharma. Why? They want to sell more drugs.

    Note: meta analysis is not a study, it is just a review of studies based on what the "investigators" decide, on their own, to be the threshold of significance.

    I have taken fish oil for 20 yrs. My triglycerides are 55, my LDL cholesterol is 130, my HDL cholesterol is 73. I don't eat fish. The doctor tells me I am at zero risk for a heart attack. Go figure.

    Or... go fish oil, and screw the disturbing "meta analysis" which pops up every two yrs.

    Search at

    http://www.ncbi.nlm.nih.gov/sites/entrez

    and see how many hits you get about the benefits of taking fish oil - from the premier research database in the world - used by all leading universities and research orgs.

    Take fish oil, not drugs.

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  15. 15. workingonit in reply to vapur 11:28 AM 9/28/12

    Thanks Vapur for reminding me about purslane. Another good source for vegetarians is flax seed. I grind two tablespoons fresh every morning, in a little coffee grinder, and mix into my oatmeal--since I believe much of the benefit of any food dissipates fairly quickly when processed (and to the extent of the processing). Therefore, fresh-ground instead of purchased as an oil, capsule, etc.

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  16. 16. greenshadow22 in reply to jstahle 06:25 PM 9/28/12

    My lungs didn't get the news I guess. I really did not have a cough.

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  17. 17. WizeHowl 05:52 AM 10/24/12

    Just sounds a bit fishy to me!

    But realistically why not just eat a piece of fish once a week and save money, and stop the pharma companies from making all the money.

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  18. 18. Lizzz 02:39 PM 3/18/13

    My story: my hair was falling out by the hand full. I started taking fish oil (4-5,000 mg a day) now for 5+years. Have had a wonderful full head of hair for years & I have been sick maybe 2x?. I am sold that fish oil is very good for you.

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  19. 19. tejul in reply to jurasketu 02:03 PM 3/20/13

    It is best to keep the omega 3 vs omega 6 ratio under 1:5. 1:1 would be ideally, but this is really hard to achieve. Take a look at this article on <a href="http://healthiack.com/health/omega-3-vs-omega-6-ratio">omega 3 vs 6 ratio</a>. The best way to equalize this ratio is to eat less omega 6 foods, and more omega 3s foods. For most of people this means eating less fat foods and start to consume more <a href="http://healthiack.com/health/omega-3-foods">omega 3 rich foods</a>. Fish are a great source of omega 3 by the way.
    regards, Tej

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  20. 20. tejul 02:03 PM 3/20/13

    It is best to keep the omega 3 vs omega 6 ratio under 1:5. 1:1 would be ideally, but this is really hard to achieve. Take a look at this article on <a href="http://healthiack.com/health/omega-3-vs-omega-6-ratio">omega 3 vs 6 ratio</a>. The best way to equalize this ratio is to eat less omega 6 foods, and more omega 3s foods. For most of people this means eating less fat foods and start to consume more <a href="http://healthiack.com/health/omega-3-foods">omega 3 rich foods</a>. Fish are a great source of omega 3 by the way.
    regards, Tej

    Reply | Report Abuse | Link to this
  21. 21. tejul 02:05 PM 3/20/13

    It is best to keep the omega 3 vs omega 6 ratio under 1:5. 1:1 would be ideally, but this is really hard to achieve. The best way to equalize this ratio is to eat less omega 6 foods, and more omega 3s foods. For most of people this means eating less fat foods and start to consume more omega 3 rich foods.
    http://heathiack.com/health/omega-3-foods.
    Fish are a great source of omega 3 by the way.
    regards, Tej

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