We modified it with a synthetic gene that would produce IGF-I only in skeletal muscle and began by trying it out in normal mice. After injecting this AAV-IGF-I combination into young mice, we saw that the muscles' overall size and the rate at which they grew were 15 to 30 percent greater than normal, even though the mice were sedentary. Further, when we injected the gene into the muscles of middle-aged mice and then allowed them to reach old age, their muscles did not get any weaker.
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