Over the next five years, Yamanaka’s group of about 20 investigators will focus on how iPS cells can help predict a drug’s side effects and elucidate problems in toxicology and disease mechanisms. For all the excitement, possibilities and rivalry bubbling in the wake of his findings, the one-time physician tempers his expectations with firm caution. “We still need a lot of basic research in terms of the safety of iPS cells,” Yamanaka reiterates. “This is a not an international competition like the Olympic Games. It should be international collaboration. This is the beginning of a long process.”
Note: This story was originally published with the title, "Turning Back the Cellular Clock."
*Erratum (10/8/12): The number of mice used was incorrect as published. The sentence should have read: "Out of 26 mice implanted with iPS cells created without c-Myc in Yamanaka's lab, none died after 100 days, compared with six out of 37 that died of tumors when c-Myc was used."