In high school biology you probably learned that every one of our body’s cells contains the same genome, or pattern of DNA—but it turns out that this is not true of the brain. Researchers at the Salk Institute for Biological Studies recently found that the DNA sequence in human neurons can vary not only from that of the rest of the body but even from one brain cell to the next.

The reason is “jumping genes,” DNA elements that can copy and reinsert themselves in different places within the genome. These mutations increase the total amount of DNA in each neuron. Geneticist Fred H. Gage and his team at Salk looked at a type of mobile element called LINE-1. Although LINE-1s are present in all cells of the body, they appeared to be active only in developing brain cells, the researchers found.

The jumping genes generate neuronal diversity, which might help the brain adapt, Gage speculates. “Many of the things that we are going to be presented with throughout our lives are unanticipated,” he says. The higher the neuronal variety in the brain, the higher the chances that it contains some cells that are capable of rising to these cognitive challenges.

Note: This story was originally printed with the title "Jumping DNA"

5 Comments

1. 1. mindsparke 02:09 PM 1/7/10

   This finding seems to be quite sensational. The possibility that our experience leads to changes in the genetic makeup of brain cells leads me to wonder what extent of variation we could see by deliberately changing our circumstances.

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2. 2. Duvsler 12:01 PM 1/28/10

   All this seems to make the perfect sense. For example; Take that child that was neglected and put in the dog pen for most of her life. Her braind evolved or should I say developped like those of her K9 friends. She barked and acted just like a dog. They tried to educate her but with out success. I think that prooves that the "Jumping Neural DNA hypothesis is correct.

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3. 3. Duvsler 12:02 PM 1/28/10

   All this seems to make the perfect sense. For example; Take that child that was neglected and put in the dog pen for most of her life. Her braind evolved or should I say developped like those of her K9 friends. She barked and acted just like a dog. They tried to educate her but with out success. I think that prooves that the "Jumping Neural DNA hypothesis is correct.

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4. 4. rspuebla 09:18 PM 1/31/10

   It is an amazing hypothesis, but for a realystic approach I think that the researchers should be propose an evolutionary approach in their future research. That is because I sustain that the life mantain their successfully manner of perform repeteadly in many species, when these performnce is properly success.

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5. 5. mrgardon 04:23 PM 10/4/10

   Does the DNA, neutons or outside influence initiate this gene jumping?

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