Kate Middleton Is Pregnant and Has Hyperemesis Gravidarum—What Is It?

The British royal was hospitalized on Monday for a rare pregnancy complication that causes nausea and vomiting so extreme it has the potential to kill















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If I get this in my first pregnancy, how likely am I to have it in the second and the third?
We've done a recurrence risk study: It's more than an 80 percent recurrence risk rate. Women who had changed partners, they had the same risk.

What's the economic cost?
There's more than $500 million in hospital charges in the U.S. yearly.* And emergency department visits are on the rise, too. It's up to over 220,000 emergency room visits in the U.S.

What steps can you take to prevent it?
We found that women tended to have it longer if they had allergies and if they had a special diet. And the special diets were lactose-free diets and veggie diets, so it may help to not have a veggie diet or lactose-free diet or kosher diet.

Tofu is high in estrogen, lactose-free milk is high in estrogen, so it could be that that's creating their symptoms.

But we don't know. There are a lot of questions and not very many answers.

*Correction (12/5/12): This sentence was edited after posting to correct the dollar amount originally stated.



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  1. 1. Ladybelle 07:49 PM 12/4/12

    How is this condition treated?

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  2. 2. Wsbirthmom in reply to Ladybelle 08:16 PM 12/4/12

    I had this and was prescribed Zofran. It was the only way I could function. It took away the extreme nausea. It was horrible. I could not get up without the medication.

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  3. 3. Ladybelle 08:39 PM 12/4/12

    I'm so sorry. My husband took that medicine when he had throat cancer. It is an awfully expensive med, for one thing!
    I suppose that the Duchess of Cambridge can afford it, but I am surely sorry to hear that she is so unwell. It will probably pass soon. I hope so, anyway.

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  4. 4. CDBSB in reply to N49th 11:07 AM 12/5/12

    June? I heard those words in the first trimester.

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  5. 5. jgrosay 02:45 PM 12/5/12

    Methodic doubts: As SciAm usually doesn't pay attention to pregnancies, funerals, and sentimental journeys of people in the class that keep tabloids and pink press workers and entrepreneurs alive and well, and SciAm is doing this with the so called "British princes", I'd like knowing: a) If the USA is or is not a Republic. b) If the USA broke apart with the Britons in the last part of the 18th Century. c) If there's a reason that can be confessed for the policy many seem having, of introducing the British "royalty" as the most "royal", most "cute", most "in", most "legitimate" and most "respectable" among the many countries that believe their political system is a "monarchy". Salut +

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  6. 6. LarryW 03:46 PM 12/5/12

    One fact (or hypothesis) about HG (and morning sickness generally) is that the hormone levels of pregnant woman spike to 100 to 1000 times normal (estrogen and progesterone). It is said, this is sudden and massive change in hormones is the precipitating cause.

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  7. 7. LarryW in reply to jgrosay 03:49 PM 12/5/12

    If you don't have anything to say, say nothing.

    Hopefully, this will mean we will never be hearing from you again.

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  8. 8. CDBSB in reply to LarryW 03:56 PM 12/5/12

    Good luck with that. Some people just love to complain.

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  9. 9. Bijoou 04:28 PM 12/5/12

    Are our lives really so dull and flat and empty that we need these Royal British Cinderella stories to make our lives worth living? How sad! I, for one, couldn't care less about the Duchess'pregnancy,her morning sickness or her wardrobe.
    However, if some highly regarded and well credentialed scientist can prove that the pregnancy was the result of Imaculate Conception, I'll join middle America in looking forward to and welcoming the New Messiah!

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  10. 10. Bijoou 04:30 PM 12/5/12

    Are our lives really so dull and flat and empty that we need these Royal British Cinderella stories to make our lives worth living? How sad! I, for one, couldn't care less about the Duchess'pregnancy,her morning sickness or her wardrobe.
    However, if some highly regarded and well credentialed scientist can prove that the pregnancy was the result of Imaculate Conception, I'll join middle America in looking forward to and welcoming the New Messiah!

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  11. 11. tommyoctober 04:49 PM 12/5/12

    Hello All: there is an evolutionary basis for many things that we interpret as abnormal...but they actually served a purpose millions of years ago, and some still until today: (1) hyperbilirubinemia, an incidence of 40-50% in neonates, occurs frequently and bilirubin is an anti-inflammatory product--useful to the newborn, except when it climbs to dangerous levels; (2) post-partum depression's evolutionary basis occured when the mother realised that there would be a new alpha male who would kill her baby---hence she would divorce herself from most of her motherly feeling and suffer the obvious depression from knowing that her baby would be killed; or if the newborn was not robust and the mother felt that it might not survive, she would save whatever resources she had (food, water) for her other offspring who had a better chance of survival and let the sickly one die; (3) lower body fat retention with cellulite (almost always in women) serves to act as a store of energy for whatever famine might approach; fat tissue also contains an abundance of aromatase, and enzyme that converts the adrenal's testosterone into estrogen----adding to her fertility. Sadly, in obese male, the same enzyme produces the same increased proportion of estrogen; (4) hyperemesis was a function of a hyperacute metabolic system that was very selective about what, if any, subtle toxins got into the mother and subsequently the baby. Obviously,this purpose is not as needed today but some women remain with minimally disturbed metabolic pathways that can produce substances that can irritate the chemoreceptor trigger zone (CTZ) in the brain's 4th ventricle (outside the blood-brain-barrier) and initiate the vomiting reflex. Thus, it's Nature's (distorted) way of protecting the mother and baby from any toxin.

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  12. 12. kencampbell in reply to jgrosay 04:57 AM 12/6/12

    Just for the record - there are a great number of we Brits who are already totally bored by this story. I wish the parents-to-be well but only in the same way as I would any other couple. I deplore the fact that, whether idiot or genius, the child of this pregnancy will eventually become head of state of my country.

    As a constitutional republican, I hope that long before this child reaches maturity we have replaced the monarchy with a president as head of state, following the Irish model of a "figurehead" president without legislative powers.

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  13. 13. jgrosay in reply to CDBSB 09:08 AM 12/6/12

    Sorry, I missed the fact that some icons are part of feelings close to the religious ones, and there is people that would react to some statements the way some muslims reacted towards Salman Rushdie's "Satanic verses". I not only have things to say, and the right to do it, but want to remind you that the true heirs of the british throne are the descentants, if there are any, of Philip II, King of Spain, who was designated heir by the only true Queen of England. We are aware that Caligula changed his horse into Consul, but truth is the truth. When starting to insult, you must remember that if you send a tennis ball, you may have back a hand grenade. Watch your step, salut +

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  14. 14. CDBSB in reply to jgrosay 11:06 AM 12/6/12

    Like I said, some people just like to complain. I did not insult, and I was not offensive. Kindly keep your hand grenades to yourself.

    I do understand that people may not want to read about British monarchy, but I hope that all of those complaining about it realize that the essence of this piece was to inform about hyperemesis gravidarum. The fact that involves a member of the British royal family isn't important. The subject of the article could have been anyone "famous" who is suffering from the condition. I'm sure the good people at SciAm are aware that their publication isn't a gossip magazine, but informing the public about a medical condition shouldn't open them up to extreme scrutiny just because a famous person was used to make the article more visible. How many people would have read this piece if Kate Middleton wasn't mentioned?

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  15. 15. ironjustice 11:40 AM 12/6/12

    Research has shown it is the iron which doctors prescribe to pregnant women that causes the mornng sickness.
    "The effectiveness of discontinuing iron-containing prenatal multivitamins on reducing the severity of nausea and vomitingof pregnancy."
    "Avoiding iron-containing multivitamins is effective in majority".

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  16. 16. CDBSB in reply to ironjustice 12:04 PM 12/6/12

    Do you have some links to these studies? If so, that would be useful information for people.

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  17. 17. ironjustice 02:01 PM 12/6/12

    Pretty much everything I put in 'quotes' , "" , can be simply 'cut and pasted' into a search engine like Google , and voila , up should pop the reference.
    "The effectiveness of discontinuing iron-containing prenatal multivitamins on reducing the severity of nausea and vomitingof pregnancy."

    http://www.ncbi.nlm.nih.gov/pubmed/19280488

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  18. 18. Ungolythe 07:45 PM 2/7/13

    My wife experienced this during her pregnancy. Fortunately it subsided as her pregnancy progressed but it wasn't fun to deal with (and that is just from my perspective, I'm sure it was much more horrible from her side.)

    Sad (only a little) but true but this story would not get near the amount of reads is the headline was "Anonymous pregnant women has HG...." Still funny how the mere mention of someone famous gets people ire up for no reason. I guess people need an excuse to troll a little.

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