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Billions of years ago, organic chemicals in the primordial soup somehow organized themselves into the first organisms. A few years ago scientists found that something similar happens every once in awhile in the cells of all living things: bits of once-quiet stretches of DNA sometimes spontaneously assemble themselves into genes. Such "de novo" genes may go on to play significant roles in the evolution of individual organisms—even humans. But how many are there?
More than anyone thought, it turns out.
The most prolific source of new genes in animals, plants, fungi and other life whose cells have nuclei involves the shuffling or duplication of bits of DNA from existing genes. It was widely thought that de novo evolution of genes was quite rare, because the proteins they code for are often large and complex—most fail to function properly if a single key component is out of place, so randomly evolving a working gene seemed implausible.
When an international team of researchers scanned the human genome for de novo genes, however, they putatively uncovered 60, three times more than once estimated. More surprising, many of these genes are active in the cerebral cortex, suggesting that de novo genes might have played a key role in the evolution of the human mind.
"The cerebral cortex in the brain plays key roles in learning, memory, language, thought, emotion, perceptual awareness and consciousness," says researcher Dong-Dong Wu, a geneticist at the Chinese Academy of Science's Kunming Institute of Zoology, co-author of a November 10 report in PloS Genetics. "Our results suggest that de novo–originated genes may be responsible for some of these characters."
A flurry of research in the past five years also had suggested that recent de novo evolution of genes was not impossible. De novo genes were first discovered in fruit flies, and have since been seen in yeast, rice, mice and primates. They were first reported in humans in 2009.
To find more de novo human genes, Wu and his team started with known human genes and eliminated those resembling genes in other primate lineages. Then they excluded human genes that also exist in primate relatives, but are disabled. The resulting 60 de novo genes were short and relatively simple. They were found to be active in a variety of tissues, including fat, lung, colon, breast, liver, muscle and lymph, but were most active in the testes and the cerebral cortex.
Sixty might not seem much given the 20,000 to 25,000 genes making up the human genome, but "we didn't used to think there were any," says geneticist Aoife McLysaght at Trinity College Dublin, who did not take part in this study. Given this number and the length of time between the split of human and chimpanzee lineages five million to six million years ago, the rate of origin of de novo genes seems to be approximately 10 to 12 such genes per million years, three times higher than past estimates from McLysaght and others suggested.
On the other hand, all the de novo genes were active only at relatively low levels in the tissues analyzed. "Thus, it could be argued that they play only weak biological roles," Wu notes. It remains uncertain what functions they do have—for instance, the researchers have not yet linked mutations of these genes with any known diseases.
Discovering what roles the de novo genes play will likely prove difficult. Tinkering with these genes in lab-grown cells might shed light on their activity, but the effects might be subtle at best and perhaps only seen at the larger scales of tissues and organs. Researchers, of course, cannot perform experiments on people, and it may prove impossible to perform effective experiments on lab animals to which these human genes are introduced; the de novo genes may have to interact with partner genes to function properly. One could try figuring out what other genes these de novo genes interact with to get an idea of what they might do, McLysaght suggests.
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9 Comments
Add CommentNow the UFO types are going to start saying "Science cannot explain why so many new genes appeared so they must have been implanted by extraterrestrials."
Reply | Report Abuse | Link to thisIn the words of The Onion "If God Had Wanted Me To Be Accepting Of Gays, He Would Have Given Me The Warmth And Compassion To Do So"
Reply | Report Abuse | Link to thisOn a sincere note, nice story Charles.
"On the other hand, all the de novo genes were active only at relatively low levels in the tissues analyzed. 'Thus, it could be argued that they play only weak biological roles,' Wu notes."
Reply | Report Abuse | Link to thisThe data on these genes is way to preliminary for that argument. Their activity could easily be dependent on products from other cell types, in which case in vitro studies couldn't accurately describe in vivo activity. Also, activity could vary greatly at different times in life (such as during embryonic/fetal development). It could be very informative to splice some or all of these into another animal and see how its development changes. Of course, the radical right-wingers would fight tooth-&-nail to prevent that from ever happening.
Fascinating. We are on the verge of achieving a complete understanding of ourselves biologically. The repercussions will be enormous, surprising, and unpredictable.
Reply | Report Abuse | Link to thisOf course, since evolution is a hoax. I demand to see all emails from those evil researchers!
Reply | Report Abuse | Link to thishumans were genetically engineered by the long ears for the purpose of slavery. We then killed them.
Reply | Report Abuse | Link to this"suggesting that de novo genes might have played a key role in the evolution of the human mind". This comes from an antiquated view of gene theory but one that is more easily grasped by the layman. The chance of even one of these genes evolving in 14 billion years is less than one over the number of atoms in the known universe and that's if the entire mass of the universe is prewarmed amino acid soup. The chance of 60 popping into existence in a few tens of millions of years with only an infinitesimal fraction of the mass of the earth to work with is par for the course for evolution.
Reply | Report Abuse | Link to thisthanks, i had not thought of that. it'll work for me.
Reply | Report Abuse | Link to thisoh heck. in my opinion, the human is still not completely evolved. far far far from it. especially in the brain.
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