Hofmann’s lab scheduled the second synthesis of this compound for April 16, 1943. It was a matter of producing a few tenths of a gram. Again, things were orderly and clean and all the safety measures required for work with poisons were followed. Nonetheless, during the final phase of the synthesis, it seemed that Hofmann unintentionally must have come into contact with the substance: “While we were purifying and crystallizing the lysergic acid diethylamides, I began to feel unusual sensations.” For the first time Hofmann became aware of this molecule’s potency. He described the sensations in a report to Professor Stoll: “Last Friday, April 16, 1943, I was forced to interrupt my work in the laboratory in the middle of the afternoon and proceed home, being affected by a remarkable restlessness, combined with a slight dizziness. At home I lay down and sank into a not unpleasant intoxicated-like condition, characterized by an extremely stimulated imagination. In a dreamlike state, with eyes closed (I found the daylight to be unpleasantly glaring), I perceived an uninterrupted stream of fantastic pictures, extraordinary shapes with intense, kaleidoscopic play of colors. After some two hours this condition faded away.” Hofmann had no idea that the experiment with the chemical compound had anything to do with this surprising effect since he was always so careful about keeping a clean workplace, and he was aware of the toxicity of ergot derivatives. However, the next day he thought that “perhaps some of the LSD solution got on my fingertips during recrystallization and a trace of the substance was absorbed into my skin.” He realized at the same time that should his conjecture hold up, this compound had unknown and very strong properties if just a trace could cause such noticeable effects.
The First Trip
Albert Hofmann had to know and decided to undertake a series of experiments, beginning with a test on himself on April 19th, 1943. Again he proceeded with great caution and chose a dosage of 250 micrograms, the smallest amount of ergot alkaloid deemed to have a noticeable effect.
But once again, strange and, initially, decidedly frightening images overcame the chemist, this time more acutely than before. According to his lab journal, his experiment began at four twenty in the afternoon when he ingested “0.5 cc of ½ pro mil tartrate solution of diethylamide peroral = 0.25 mg tartrate. To be taken thinned with ca. 10 cc water.” At five pm he notes: “Beginning dizziness, anxiety, disturbed vision, paralysis, urge to laugh.” Two days later he adds: “Cycled home. Severest crisis from six to eight pm” and refers to a special report because he can barely record the last entry. He is at once certain that his experiences on April 16th stemmed from unintentional ingestion of a small amount of LSD-25. The experiences were the same, but this time more intense and profound.
During the war, fuel was difficult to find. Gasoline was rationed and available for very few private vehicles. Indispensable commercial vehicles such as tractors and trucks were fitted with wood gasifiers. At that time, even in Switzerland only a few wealthy could afford an automobile and taxis were not available. That is why Hofmann did not have someone drive him home; instead, his lab assistant, Susi Ramstein accompanied him by bicycle. He had the impression that they made little headway, but she later assured him that they cycled very fast and she had to pedal hard to keep up with him. The rows of houses took on threatening forms, the street seemed wavy, and the few persons they met changed into distorted shapes. The distance between the laboratory and his home was ten kilometers, with a few gentle inclines on the way.
Once they reached his house, Hofmann asked Ms. Ramstein to call his doctor and to bring him a glass of milk from the neighbor woman as an antidote: He feared a fatal poisoning. Dizziness and faintness alternated. Exhausted, he went into the living room and lay on the sofa. Just as on the way home, the familiar surroundings in the cozy home looked distorted and eerie. The walls and ceiling appeared to bend and arch, furniture took on grotesque forms and appeared to move. He asked for more milk. He hardly recognized the neighbor who brought him more than two liters of milk. Instead, he perceived her as “a nasty, insidious witch with a colored mask.”