Albert Hofmann was impressed by his discovery10 and by the intensity of his experiences during that first self-experiment with LSD-25 which would long resonate for him. He knew of no other substance with such profound psychological effects at such a low dosage that so dramatically altered experience of the inner and outer worlds in human consciousness. Hofmann found it remarkable that he was able to recall details of his LSD intoxication and explained it with the hypothesis “that no matter how perturbed someone’s worldview was at the height of the trip, the part of consciousness that registers experience was unimpaired.” He was equally amazed that he remained aware of it as an experiment on himself yet was unable to voluntarily alter it and banish the “LSD-induced world.” Just as surprising and welcome was the absence of any noticeable hangover afterwards; rather he felt left in excellent physical and mental condition.
Three days later, Hofmann presented his detailed report to Arthur Stoll and Professor Rothlin, the director of the pharmacological department. “As might be expected, it met with incredulous astonishment,” he recalled. They both immediately asked him whether he had made an error in dosage. It was clear to them that no psychotropic substance was known to be that effective at a micro dosage level. The last doubts were erased only when Rothlin and Stoll both cautiously tried dosages of LSD one-third the strength of Hofmann’s trial dose and had nearly as impressive results. In subsequent trials, Hofmann never ingested a comparable dosage again and described 250 micrograms as an “overdose.” He was astonished that the “tripping generation” of the sixties considered his first dosage to be the standard measure.
His spectacular bicycle ride from the Sandoz factory through the outskirts of Basel and on beyond the city limits to his house became the stuff of legends. Since 1984, April 19th has been celebrated as “Bicycle Day” among pop-culture LSD fans. It was initiated by Thomas B. Roberts, emeritus professor of educational psychology. Americans in particular found the idea of a bike ride while on LSD amusing and admirable. Back then, hardly anybody in that land of boundless possibilities used bicycles and certainly not in the condition Hofmann was in on his original trip.
Looking back, Hofmann thought about the circumstances and significance of his discovery: “From a personal perspective, without the intervention of chance, I think the psychedelic effects of lysergic acid diethylamide would not have been discovered. It would have joined the tens of thousands of other substances that are produced and tested in pharmaceutical research every year and are relegated to obscurity for lack of effect and there would have been no LSD story.
However, in light of other significant discoveries of the time in medical and technical fields, the discovery of LSD could be considered less a matter of chance than of being called into the world as part of a higher plan.
In the 1940’s, tranquilizers were discovered and proved to be a sensation for psychiatry. As their name expresses, tranquilizers cover up emotional problems whereas LSD is at the opposite pole of pharmacology; it reveals problems, making them more accessible to therapeutic intervention.
About the same time, nuclear energy became technically usable and the atomic bomb was developed. A new dimension of threat and destruction had been created compared with earlier energy sources and weapons. That corresponds to the increase in potency in psychotropic drugs such as mescaline to LSD, of a factor of 1:5,000 to 1:10,000.
One might suppose that the discovery of LSD was not a coincidence but drawn to attention by the Weltgeist. From this perspective, that would make the discovery of LSD no longer a matter of coincidence. Further reflection might lead one to think that its discovery was predetermined by a higher force and emerged as people began to contemplate prevalence of the materialism of the past century; LSD, an illuminating psychotropic drug, appearing on the way to a new, more spiritual age.