No Bones about It: Ancient DNA from Siberia Hints at Previously Unknown Human Relative

For the first time, researchers describe a new type of human ancestor on the basis of DNA rather than anatomy















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"The data that they provide is certainly of the nature to arrive at the conclusions that they do," comments Stephan Schuster of The Pennsylvania State University, who worked on the recent sequencing of Archbishop Desmond Tutu's nuclear genome as well as the nuclear genome sequencing of a woolly mammoth. "All the detected sequence differences clearly indicate that this is a novel variant of a [hominin]."

Paleoanthropologist Ian Tattersall of the American Museum of Natural History in New York City noted that the finding should not necessarily come as a surprise. "We know the fossil record is far from complete, but what we have already shows that the [hominin] evolutionary bush is quite luxuriantly branching," he remarks. "One more branch is not something that ought to give us indigestion."

The association of the mystery hominin with those Middle and Upper Paleolithic artifacts is peculiar though, because elsewhere in Eurasia they have only turned up with Neandertal and modern human remains. Krause notes that it is possible that the pinky bone originated in an older, deeper layer of the cave sediments and over time got mixed in with the overlying artifacts. Thus far, however, there is no evidence for extensive perturbation. Another possibility, he says, is that the finger bone is that of an early modern human who carried an ancient mtDNA as a result of interbreeding between his or her ancestors and this previously unknown hominin group.

But other experts are not so sure about the team's interpretation of their data. "I don't know—and nobody else does—how many base-pair changes make a new species," says Erik Trinkaus of Washington University in Saint Louis, an authority on Neandertals and early modern humans. "I would like to have more than the number of mtDNA base pair differences to go on."

"The result doesn't mean that they've found a new species, and I don't believe it requires a separate pre-Neandertal migration out of Africa," argues John Hawks of the University of Wisconsin–Madison, whose research focuses on human genetic evolution. "Those explanations are both compatible with the result, but I don’t think the data require them yet." Hawks notes that the history of an mtDNA sequence—which is just a tiny fraction of a person's total DNA—does not necessarily reflect the history of a species.

A comparably distinctive nuclear genome sequence would significantly strengthen the claim that the Denisova mtDNA represents a previously unknown type of hominin. To that end, Krause and Pääbo are launching a Denisova genome project to obtain a full nuclear genome sequence from the bone that yielded the novel mtDNA. Comparisons of this genome with the full genome sequence they have obtained for the Neandertal as well as with the genomes of people living today could yield insights into the genetic changes that defined H. sapiens. "At the end we get more information about the big question [of] what makes humans humans," Krause reflects.

Meanwhile, paleoanthropologists are eager for more fossils to confirm the DNA-based claim. With luck, continued excavation at Denisova cave this summer will turn up additional remains—and put a face on this long-lost relative.



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  1. 1. frgough 07:52 PM 3/24/10

    Here's a question I've never found the answer to. DNA is an unstable molecule. What's it's half-life? I find it hard to believe an inherently unstable molecule can persist for thirty thousand years.

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  2. 2. Karlin 08:26 PM 3/24/10

    DNA survives for millenia by being re-created every time a newborn comes along, through egg and sperm combining. This is really interesting, and it is the basis of being human beings, and of our human doings. Humans beings doing readings on being human is to be doing what only human beings can do!!

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  3. 3. Karlin 08:26 PM 3/24/10

    DNA survives for millenia by being re-created every time a newborn comes along, through egg and sperm combining. This is really interesting, and it is the basis of being human beings, and of our human doings. Humans beings doing readings on being human is to be doing what only human beings can do!!

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  4. 4. ihitnails 01:53 AM 3/25/10

    I heard of a theory that Neanderthals didn’t die off, but were assimilated by Homoerectus (spell?). If that’s the case, what if Asians came from a mixture with Peking man? Could this “new species” be between Neanderthal and Peking man? With this theory, modern man should be called Homo Homogeneous, and If not now, then soon! (Although not in our lifetimes) With the way we move about the world and the stigmas of traditions are dropping. The future sees us as all the same (if our differences don’t kill ourselves first.)

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  5. 5. JamesT in reply to fisixisfun 10:07 AM 3/25/10

    Sigh.
    Already with the name calling.
    Don't you have anything useful to add to the conversation?

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  6. 6. PotatoChip 10:30 AM 3/25/10

    Ihitnails: In scientific circles, there are two hypotheses about the emergence of modern humans. One is called the "multi-regional" hypothesis and the other is called the "recent single-origin" hypothesis. You are referring to the former, but it’s the latter that is considered to be the broadly accepted model. You can do your own research on these. It’s not my place to say which is correct, but researchers say that the weakness of the "multi-regional" hypothesis is that there is no supporting DNA evidence for it. In other words, DNA research shows that all living people today have a recent common ancestor and that there is no contribution from any other human branch, including Neanderthals.

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  7. 7. stikinsekt in reply to JamesDavis 11:05 AM 3/25/10

    So what you're saying is that if evolution by natural selection is how species come into being, then there would be only one species.
    Surely you can see that the existence of one species will itself alter the environment, providing new possibilities for other survival strategies? For instance, if a creationist poos in the woods there will be all manner of species who are able to use the energy within the faecal matter. It is unlikely, although not impossible, that another creationist will choose to make use of it.
    That is what an ecosystem is, and it is within such systems that evolution occurs. Life in these complex systems does not amount to a monolithic 'either/or' where only one species can win.
    Surely you can see that.

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  8. 8. stikinsekt 11:05 AM 3/25/10

    So what you're saying is that if evolution by natural selection is how species come into being, then there would be only one species.
    Surely you can see that the existence of one species will itself alter the environment, providing new possibilities for other survival strategies? For instance, if a creationist poos in the woods there will be all manner of species who are able to use the energy within the faecal matter. It is unlikely, although not impossible, that another creationist will choose to make use of it.
    That is what an ecosystem is, and it is within such systems that evolution occurs. Life in these complex systems does not amount to a monolithic 'either/or' where only one species can win.
    Surely you can see that.

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  9. 9. alexoneal 03:28 PM 3/25/10

    Someone wrote, "I feel sure that there is an intelligent design to all species to keep that species unique and separate from other species...if there wasn't, then every living thing on this planet would look exactly alike."

    How, then, do you handle the live, directly observable interaction between certain snakes and snails of Southeast Asia? The snakes have developed mouths with handedness (more teeth on one side than the other), which are better able to eat some snails whose shells curve in a certain direction. The snail population has likewise shifted in response to this predation.

    Research Masaki Hoso's team studied this extensively and released data in 2007. The team said that "The remarkable diversity of sinistral snails in Southeast Asia may be attributable to ‘right-handed predation’ by snakes."

    http://www.livescience.com/animals/070308_right_snakes.html


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  10. 10. jgrosay 06:04 PM 3/25/10

    mt DNA and Y chromosome DNA are somehow the two dead end in human genome. There seems to be a modern trend to study personal ancestry by analyzing haplogroups of these 2 DNAs, but the rest of genome between the two extremes of Y and mt DNA contains a lot of data on ancestry too. In studying ethnic background of cultures, there is an easier to read fact that gives also hints: food cooking recipes. Many of us are aware of some kind of chinese food, presented wrapped inside a pasta sheet. If you watch enough ethnology films, you'll realize that this kind of cooking is found with nearly no changes in Siberian tribes. As narrow eye openings, high cheeks ad short noses are an adaptation to avoid freezing of acral parts of body in extremely cold weather, the conclusion that chinese races have Siberian roots, as native americans have, is easy to make. Modern greek cuisine has lots of common recipes with turkish ones, not suprising when one considers that turkish invaders went several times back and forth of this land. There are people that say no people having strong genetical connection to the greeks that build Partenon currently remain, but up to 25% of the spaniard people of today have the so called greek foot, the second toe being longer than the first one, as in the classical greek sculptures. What happened to those guys? Surnames are also a clue to more recent ethnic background data, but here also, a lot of artificial changes took place for convenience reasons. How deep the Mormon registry on humankind family tree arrived?. There is a lot of funny science, enjoy it

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  11. 11. Billy Gambela 07:21 PM 3/25/10

    I Love This Stuff!!
    http://billygambelaafroasiaticanthropology.wordpress.com/

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  12. 12. Billy Gambela 07:22 PM 3/25/10

    I Love this Stuff!!
    http://billygambelaafroasiaticanthropology.wordpress.com/

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  13. 13. jtdwyer in reply to ihitnails 08:10 PM 3/25/10

    ihitnails - I kinda like that story too, feeling some affinity with Neanderthals. Kinda like relating to T-Rex as a kid.

    However, I also heard a story stating that there's more genetic diversity among tribal groups in East Africa than there is between Asians and Europeans, or any other 'race'.

    These two stories seem to be mutually exclusive, since Neanderthal's genes seem to be quite different from modern humans, although one Neanderthal in the family tree might not be very noticeable by now. However, if there are few Neanderthal genes left in the pool it seems unlikely that they could be producing distinguishing characteristics among groups.

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  14. 14. leogirl8189 in reply to frgough 11:36 PM 3/25/10

    to frgough,

    DNA is actually a very stable molecule which is why it is used to carry our genetic information. The half life of DNA in ice is 1.1 million years.

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  15. 15. GBristol 10:52 AM 3/29/10

    Very exciting. But when will scientists finally recognise the enormous evidence that exists for the Almasty/Bigfoot as a living hominoid? They need to get to grips with this and stop ridiculing the subject, as it is possible that this is what this new species discussed in this article is (as well as many of the other human-type fossils that so far defy categorisation) . There is far more evidence for the existence of the Almasty (a Eurasian name for the Bigfoot) than there is for many already recognised mammal species. Indeed there have been many sightings of the Almasty in the Altai mountains where this new hominoid fossil was found. Overall, the evidence for the existence of the Almasty/Bigfoot is: several bones, three confirmed DNA sample from Asia and Norther America (identified as 'unknown primates), thousands of documented sightings from across Eurasia and the US states, numerous enormous human-type faeces, many thousands of footprints, and a large body of knowledge of their behaviour from the small groups of Russian researchers who have been studying the creatures for the last four decades. At least, this new discovery is taking scientists closer to eventual recognition, as they are slowly realising that a greater vcariety of hominoids exists that they thought and that some of these were very, very recent. For information on the Russian research on the Almasty see: http://www.stgr-primates.de/

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  16. 16. zymurgy13 11:32 AM 3/29/10

    frgough
    Unlike a radioactive isotope, there is not a definitive "half-life" of DNA. Many factors influence it's degradation: temperature, light(UV/Sunlight),humidity etc...contribute to how efficient both endogenous and exogenous DNAses work(enzymes that chew up DNA). The best case scenario for prserving ancient DNA is very cold, very dry and very dark.

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  17. 17. PotatoChip 03:09 PM 3/29/10

    "enormous evidence that exists for the Almasty/Bigfoot as a living hominoid"

    This is a joke, right?

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  18. 18. GBristol in reply to PotatoChip 08:33 AM 3/30/10

    Re: enormous evidence for the Almasty/Bigfoot - no, its is not a joke. Thousands of sightings (by locals and researchers, including many full encounters), thousands of footprints, DNA samples, the creature is known by local tribes across a huge range of Siberia etc. etc. Drop the dismissive attitude and find out the information for yourself.

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  19. 19. PotatoChip 11:24 AM 3/30/10

    GBristol, anyone who knows a little bit about science knows that sightings are not evidence. That would make anyone who knows something about science doubt whether you know very much about science. Hence the (deserved) dismissive attitude.

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  20. 20. GBristol in reply to PotatoChip 02:39 PM 3/30/10

    PotatoChop - no need to be impolite. I know very well what science and evidence are (studied biology at Cambridge University, thank you). Sightings are not scientific evidence and I did not claim they were, but they are nevertheless a form of evidence (such as in court and for policy-making). But that is by the by. If you read what I wrote in full, you will see that I mentioned DNA samples, bones and faeces. The point I was making is that there is more scientific (plus much other) evidence for this creature than there is for other already recognised mammal species, and hence this subject deserves proper investigation by the scientific community (China is the only country which is officially researching the subject). This subject is so important but very hard to progress because people are closed minded (one of the last social taboos left over from religious thinking that we humans are unique, perhaps?). If you have any interest, please check out the subject for yourself.

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  21. 21. PotatoChip 03:15 PM 3/30/10

    GBristol, I did read what you wrote in full. You said, "Thousands of sightings" in direct response to what amounts to "enormous evidence". Now you’re backpedaling on the relevance of sightings. Why did you mention them at all? One wonders. They have no bearing whatsoever in scientific research.

    If the DNA has been identified as "unknown primate", then it isn’t evidence "for" big foot, is it?

    Your stance is schismatic. On the one hand, you insist that scientists don’t take this view seriously, while on the other hand, you insist that the scientific research is on your side. Which is it? Are the scientists with you or against you?

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  22. 22. GBristol 09:08 AM 4/12/10

    Hi PotatoChop. Oh dear. Sightings are very relevant. Scientific research normally starts with observations (eg. observation of a falling apple suggested existence of gravity etc.). There would be no reason to research the Almasty/Bigfoot (or any topic), if there were no indications that it might exist. The DNA being identified as 'unknown primate' indicates there is a (scientifically) unidentified primate in the northern hemisphere (ie. 'unknown' in this context means scientifically unknown). Finally, there is a difference between scientific evidence and the scientific community. So far, all of the evidence has come from researchers who are not part of the established scientific community. I would like to see mainstream scientists engaging in this subject, producing their own evidence, publishing papers etc, and then the debate can be put on a more authoritative footing. Does that make sense?

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  23. 23. PotatoChip 10:27 AM 4/14/10

    GBristol: Your comparison of Bigfoot sightings to falling apples doesn’t work. The latter is reproducible and yields reliable observational data, while the former does not. The motion of objects (falling, orbiting etc.) can be studied and analyzed. Sightings amount to nothing more than hearsay. They produce no observational data. I think you can see the difference. The controlled observation of moving objects qualifies as evidence, while sightings of Bigfoot do not.

    Call it "unidentified" or "unknown". Any way you slice it, you are NOT talking about evidence "for" Bigfoot. You can’t go to the scientific community saying that you have some DNA that hasn’t been identified and convince them to study Bigfoot. The non-scientists you mention should try to get a real scientist to establish where the DNA falls in the primate tree. No need to mention Bigfoot. Just do DNA comparisons to find out on which primate branch the DNA belongs. Then you would actually have something you could call evidence. Until then, you don’t have any.

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  24. 24. buddhacosmos in reply to alexoneal 11:27 AM 5/14/10

    i think you might be refering to my complaint that MORBIDITY , FECUNDITY and COMPETITION , if they were the only factors in evolution, then we would only have one eternally living agressive and exponetially proliferating canabilistic organism left. this theory doesnt explain adaptation, and the mutual.

    i did not mean to imply creationism. but there is more at work, proportionately more than codon alterations, to answer for your snake and snail. and that is the synthesis the ecosystem makes of evolution.

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  25. 25. wildthing 05:46 PM 5/19/10

    So they may have all interbreed and we have a much bigger diversity than we think!!

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  26. 26. wildthing in reply to Karlin 05:56 PM 5/19/10

    it is not all human beings doing what human beings do but also human beings going where no human beings have been going before and doing it with the other human beings that are there being humans and doing what human beings do while going about what humans beings go about doing while being human beings doing it too.

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  27. 27. wildthing in reply to Karlin 06:01 PM 5/19/10

    and the eggs are always eagging the sperm on all the time but only the ones that wag their tails the most get close to making the most of it and getting egg on their face!

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  28. 28. PotatoChip 04:32 PM 5/21/10

    buddhacosmos: Regarding morbidity, fecundity and competition, you said that "if they were the only factors in evolution, then we would only have one eternally living agressive [sic] and exponetially [sic] proliferating canabilistic [sic] organism left."

    Still at it with the straw man, I see (as well as a plethora of inexplicable misspellings). You left out (among other things) cooperation. Never mind that a population can be very well-adapted to its environment only to be wiped out by a virus or by changing climate (which negates your ridiculous and utterly false claim). It is also true that symbiotic relationships abound (which should help you see why you have again presented a straw man argument). The core principle that you reject is that natural selection operates on genetic diversity, which stems essentially from mutation and viral injection (transgenesis). Then, of course, there’s recombination, which yields novel gene combinations - and then there are regulator genes, which turn genes on and off - and so on and so on. Modern evolutionary theory most certainly does explain adaptation. But the only way to see that would be to actually understand the principles, which, as you have repeatedly demonstrated, you don’t.

    Instead, you propose the following stunningly vague hypothesis: "the synthesis the ecosystem makes of evolution." That doesn’t mean anything. If you think it does, please elaborate.

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