Cover Image: April 2008 Scientific American Magazine See Inside

New Weapons Against Cocaine Addiction [Preview]

Drug therapies show promise in the battle against addictive stimulants














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In Brief

Counteracting Cocaine

  • Doctors have few pharmacological remedies for addiction and no standard drug therapy for cocaine dependence. A decrease in cocaine use by 10 percent could save the U.S. $745 million in medical, law-enforcement and other cocaine-related expenses.
  • Experimental therapies, including one marketed for epileptic seizures and another for the sleep disorder narcolepsy, appear to help addicts quench or diminish the thirst for cocaine.
  • Scientists are also trying to enlist the immune system to thwart cocaine abuse.

Many people still chalk up the destructive behavior of a drug addict to a lack of willpower or weakness of character. To a neuroscientist, however, drug addiction is a psychiatric illness that develops when the repeated use of narcotics disrupts brain chemistry. Such a chemical disturbance cries out for a chemical solution—that is, a drug treatment.

Doctors have few pharmaceutical remedies for drug addiction, which is often resistant to talk therapy. Relapse rates run as high as 40 to 60 percent for many types of substance abuse. Heroin addicts often benefit from methadone, a synthetic opioid that thwarts cravings by substituting for some of heroin’s effects; naltrexone, an opioid receptor blocker, helps alcoholics kick their habit by reducing the desire for alcohol. But most victims of drug dependence are left with no antidote to the neurological havoc their habit has wrought in their brain. “We have very few medications for the treatment of addiction,” says Nora D. Volkow, director of the National Institute on Drug Abuse (NIDA), “and it’s urgent” that more such drugs are developed.


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  1. 1. health 02:51 AM 9/6/08

    Cocaine addiction is very harmful for society. There are many Available across the world. They provide excellent services for recovery of dependency. People should be aware from the harmful affects of these substances.

    http://www.addiction-treatments.com/

    Reply | Report Abuse | Link to this
  2. 2. deepu 05:24 AM 12/12/08

    Cocaine drug rehab center provides the effective therapeutic treatment to drug abusers in the short period of twelve moths. <A Href=http://www.edrugrehabs.com/SubstanceAbuse/Cocaine-Addiction-Treatments/Rehabs/index.html>Cocaine drug rehab center </A>provides effective treatment and services to their patients. If you want to more information about the cocaine drug rehab centers so you can visit the web site.

    http://www.edrugrehabs.com/SubstanceAbuse/Cocaine-Addiction-Treatments/Rehabs/index.html

    Reply | Report Abuse | Link to this
  3. 3. pressingtheissue 06:20 AM 1/26/11

    I like the idea of a "virus" helping to fight Cocaine addiction, as long as it is safe.
    http://www.pressingtheissue.com/2011/01/vaccine-blocks-cocaine-high-in-mice-approach-could-also-stop-addiction-to-other-drugs-including-heroin-and-nicotine/

    Reply | Report Abuse | Link to this
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