APRIL 1957

GRAFTED TISSUE--"We discovered that the power to react against homografts could be prevented from developing if we injected an animal at a very early age with cells from the donor strain--most conveniently cells of the spleen. In adult mice the injection of such cells ¿increases the mouse's resistance to a graft from the donor. But if the spleen cells are injected in a mouse in the fetal stage or very shortly after its birth, the opposite happens: the mouse becomes tolerant of grafts from the strain that provided the spleen cells, though it remains intolerant of homografts from mice of other strains. --P. B. Medawar" [Editors' note: Medawar shared the 1960 Nobel Prize in Physiology or Medicine for his work on acquired immunological tolerance.]

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