Although most people in developed countries get plenty of calories daily, their diets are often lacking in key nutrients that their bodies have evolved to expect. Omega-3 polyunsaturated fatty acids, such as those found in fish and walnuts, are one category of crucial ingredients that the body cannot make on its own. Although these beneficial fatty acids are known to be good for heart health, researchers are just beginning to learn how omega-3s impact our brains—and by extension, our moods and behavior.
Lipids are integral to the central nervous system, and as studies of statins and diabetes drugs have shown, dropping levels of some lipids can have deleterious cognitive effects. Omega-3 deficiencies specifically have been linked to mood disorders, such as depression, but the underlying neural mechanism has been subject to debate.
New research in mice, published online January 30 in Nature Neuroscience, offers insights into just how dietary intake of these fatty acids might alter the brain's function. (Scientific American is part of Nature Publishing Group.)
"Our results can now corroborate clinical and epidemiological studies which have revealed associations between an omega-3/omega-6 imbalance and mood disorders," scientists behind the new study commented in a prepared statement.
The group, led by Mathieu Lafourcade of The French National Institute for Health and Medical Research (Inserm) Magendie Neurocenter in France, found that mice reared on an omega-3 deficient diet had lower levels of polyunsaturated fatty acids, such as docosahexaenoic acid (DHA), in their brains as well as higher overall levels of the more harmful omega-6. These mice also went on to exhibit a range of depressive symptoms in behavioral tests. The deficient animals, for example, gave up more easily in a classic forced swimming test, were less inclined to explore, and were more inclined to stay near the wall of a cage, "a widely accepted index of anxiety," the researchers noted in their study.
More specifically, the team found that a diet lacking ample omega-3 decreased the function of presynaptic cannabinoid receptors, part of the brain's signaling network that is thought to be involved in pain and appetite regulation. By getting down to synaptic levels in the brain—even if only in mice—the researchers seem to have taken a step toward explaining why omega-3 trials in humans have shown some success in treating mood disorders.
Others who have been following the links between nutrition and neuroscience are excited about the findings. "I think it's an important paper," says Gregory Asnis, a professor of psychiatry at the Albert Einstein College of Medicine in the New York City and who was not involved in the new study. "This raises concern [about] the true effect of omega-3 on behavior in human beings."
Omega-3 has already been used to treat depression in adults as well as children, but as Asnis points out, "not every [depressed] patient has omega-3 deficiencies." And although clinical data has shown it to be effective in some patients, "it's not a knock-your-head-over kind of data," he says.
Researchers can now measure a person's omega-3 levels relatively accurately via a blood test. Now that this test is available, "this research is really going to blossom," Asnis says. He suggests that screening might soon become routine for people with depression as well as other key populations, such as pregnant women.