Cells that permanently stop dividing—that become “senescent”—have long been known to be a defense against cancer: if damaged cells can’t replicate, they can’t form tumors. Recently, though, investigators have learned that senescent cells can at times prod other cells to become malignant, as David Stipp notes in “Quiet Little Traitors,” in the August 2012 issue of Scientific American. Here, Judith Campisi, of the Buck Institute for Research on Aging, describes how senescent cells cause such havoc and how they can contribute, not only to cancer, but to an array of age-related ills. She also speculates on possible interventions.

1 Comments

1. 1. Michael M 06:44 PM 8/13/12

   Stress in the general sense, always induces some low-level inflammation and/or its precursors. This is to reiterate Dr. Campisi's words on the physiological specifics.
   Different cultures have developed different ways to reduce stress, but individuals can follow impulses unique to themselves to do so. Our present general worldwide culture insufficiently addresses this matter, due to the problem inherent in large populations and urban concentration. There is little relief from social stress, the most predominant source.
   
   You will notice the term epigenome in her discussion, This is highly relevant, and anyone interested on a professional or clinical basis, if not up-to-date, will do well to become conversant with the disciplines involved in, and recent developments in epigenetics.

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