Steps toward a Bionic Eye

Artificial retinas that allow the blind to see














Share on Tumblr



Image: Vitor Costa

  • The Wisdom of Psychopaths

    In this engrossing journey into the lives of psychopaths and their infamously crafty behaviors, the renowned psychologist Kevin Dutton reveals that there is a...

    Read More »

The human eye is a biological marvel. Charles Darwin considered it one of the biggest challenges to his theory of evolution, famously writing: that “To suppose that the eye with all its inimitable contrivances for adjusting the focus to different distances, for admitting different amounts of light, and for the correction of spherical and chromatic aberration, could have been formed by natural selection, seems, I freely confess, absurd in the highest degree.” Of course he did go on to explain how natural selection could account for the eye, but we can see why he wrote these words under the heading of “Organs of Extreme Perfection and Complication.”

The complexity and perfection of the eye has meant that, to date, it’s been all but impossible to reproduce its function artificially. Artificial hearts, kidneys (albeit outside the body), and ears (cochlear implants) are all in widespread medical use -- but not eyes.

That might be about to change. In a remarkable achievement, a team of ophthalmologists and engineers has managed to partially restore vision to the blind, using an electronic device which acts as a replacement for the retina. The results are reported in a paper by Professor Eberhart Zrenner, Director of the Institute for Ophthalmic Research at the University Eye Hospital in Tuebingen, Germany.

The implant consists of a tiny panel, 3 by 3.1 mm in size, containing a 38 by 40 array of 1,500 light-sensitive microphotodiodes. These sensors detect light, and control the output of a pulsed electrical current. The brighter the light, the stronger the resulting current. Each sensor has its own microelectrode, and these are placed in contact with nerve cells in the retina, called bipolar cells, the first step on the pathway from the eye to the brain. The sensors therefore mimic the way the eye’s own photoreceptor cells normally function, turning light into a pattern of electrical impulses.

The implant is not a complete artificial eye. It relies on an intact eyeball, an intact retina with functioning bipolar cells, and an optic nerve to convey the information to the brain. This means that the technology is only useful in forms of blindness caused by selective damage to photoreceptor cells.

However, such blindness is unfortunately common. Retinitis pigmentosa is a disease that causes progressive loss of vision, as the photoreceptor cells degenerate, and eventually die. There are many different forms of the disorder, each caused by mutations in a different gene. In some people, the loss of vision is gradual, and they remain able to see for most of their lives. In others, it rapidly leads to blindness. It’s estimated that about 400,000 Americans suffer some form of the disease.

Zrenner and his team implanted their device in three patients, all of whom had been born with normal vision, but had become almost totally blind due to retinal degeneration. Two of them suffered from retinitis pigmentosa, while the third had a similar disease.

The surgical procedure was, naturally, delicate. It involved inserting a metal tube behind and into one of the patient’s eyes, through which the implant was put into place. The chip comes connected to a cable that provides it with power from an external battery. It also allows the patient to control the sensitivity of the electrodes – essentially, manually adjusting the “brightness” of the image, to compensate for changes in the overall level of light. This is something that the eye normally does so effortlessly that we’re rarely aware of it.

So what happened? All three patients regained vision to some extent. Patient 2, a 44 year old man with retinitis pigmentosa, experienced the most dramatic benefits. He began to lose his sight at the age of 16. The first problem he noticed was a difficulty seeing at night, a common early symptom. By the time of the study, he was virtually blind, although he could still tell the direction from which a light was shining.


9 Comments

Add Comment
View
  1. 1. akmangalick 10:53 AM 2/15/11

    We are rapidly approaching the future that we read about in decades-old sci fi novels.

    Reply | Report Abuse | Link to this
  2. 2. greyseraphim 11:54 AM 2/15/11

    I would imagine induction would be a better way to power the chip than with a wire. Anyways, sensory bio-tech is showing a lot of promise for widespread application.

    Reply | Report Abuse | Link to this
  3. 3. scientific earthling 05:10 PM 2/15/11

    The eye is anything but perfect. A concave mirror with a sensor dangling at its focal point would do a better job.

    Reply | Report Abuse | Link to this
  4. 4. DarkAlex 06:46 PM 2/15/11

    I love developments in the bionic field. It seems that bionics and robotics can solve a wide array of every problem that humans face.
    And that, in my opinion, is the purpose of science.

    Bionic eye seems especially important because we can replace lots of other parts people may have that are deficient.

    Reply | Report Abuse | Link to this
  5. 5. Steven Brown 08:51 PM 2/15/11

    The refinement and elaboration in the evolution of the eye can be explained by taking into account that eyes started out very primitive in primitive organisms. As more highly developed species evolved from these primitive ancestors, the structures of the eye also evolved.

    Reply | Report Abuse | Link to this
  6. 6. Wayne Williamson in reply to scientific earthling 08:14 PM 2/16/11

    aah...but its the connections that make the difference...

    Reply | Report Abuse | Link to this
  7. 7. thechiropages 01:13 AM 2/17/11

    Thanks in advance for your cooperation with the above conditions. I hope you find it useful.It helped me with ocean of knowledge so I really believe you will do much better in the future I appreciate everything you have added to my knowledge base .Degenerations of the outer retina such as retinitis pigmentosa (RP) lead to blindness due to photoreceptor loss. There is a secondary loss of inner retinal cells but significant numbers of bipolar and ganglion cells remain intact for many years. Currently, no therapeutic option to restore vision in these blind subjects is available. Short-term pattern electrical stimulation of the retina using implanted electrode arrays in subjects blind from RP showed that ambulatory vision and limited character recognition are possible.
    Regards,
    <a href="http://www.thechiropages.com/">chiropractor</a>

    Reply | Report Abuse | Link to this
  8. 8. Quinn the Eskimo 02:01 AM 2/18/11

    okay, but what will this do for my biometric door lock? Can you buy the same model as I have or will we have rotating iris'?

    Don't forget having emerald gray green eyes with yellow highlights!

    How will the police know if I've been drinking?

    Will I have to replace it with a Compact Fluorescent version?

    Reply | Report Abuse | Link to this
  9. 9. bucketofsquid in reply to scientific earthling 05:27 PM 2/25/11

    Prove it.

    Reply | Report Abuse | Link to this
Leave this field empty

Add a Comment

You must sign in or register as a ScientificAmerican.com member to submit a comment.
Click one of the buttons below to register using an existing Social Account.

More from Scientific American

Follow Us:

See what we're tweeting about

Scientific American MIND

More »

Free Newsletters


Get the best from Scientific American in your inbox

Solve Innovation Challenges

Powered By: Innocentive

  SA Digital

Latest from SA Blog Network

  SA Digital

Science Jobs of the Week

Email this Article

Steps toward a Bionic Eye

X
Scientific American Mind

Subscribe Today

Save 66% off the cover price and get a free gift!

Learn More >>

X

Please Log In

Forgot: Password

X

Account Linking

Welcome, . Do you have an existing ScientificAmerican.com account?

Yes, please link my existing account with for quick, secure access.



Forgot Password?

No, I would like to create a new account with my profile information.

Create Account
X

Report Abuse

Are you sure?

X

Institutional Access

It has been identified that the institution you are trying to access this article from has institutional site license access to Scientific American on nature.com. To access this article in its entirety through site license access, click below.

Site license access
X

Error

X

Share this Article

X