Patients with Parkinson’s disease often have trouble with walking. Either they cannot take the first step, or they cannot stop moving when they reach their destination. The problem is not with the steps themselves but with starting and stopping the action—a pervasive difficulty that affects every aspect of daily life. Now research has finally pinpointed the neurons in the brain that initiate and end movements.
Rui Costa of the Champalimaud Neuroscience Program in Portugal and Xin Jin of the National Institutes of Health designed a task for mice that was the equivalent of taking eight steps. If the mice pressed a bar exactly eight times, no more, no less, they received a reward. Costa and Jin implanted tiny electrodes in each mouse’s brain to record the activity of neurons within the striatum, a structure deep in the brain known to be involved in motor commands. They found that some neurons became active right before the mouse started to press the bar and other neurons became active right before stopping.
To confirm that these neurons were indeed responsible for starts and stops, the researchers then genetically altered mice to lack the neurons, and subsequently the mice could not learn the task. They were slow to begin pressing the bar, and they tended to randomly stop in the middle of the task. These mice did not have trouble with movements per se, Costa explains, but like people with Parkinson’s or Huntington’s disease, with starting and stopping a task properly. The work should help scientists understand precisely what goes wrong in the brains of patients and help them design better therapies, Costa says.
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Add Commentso its a type of neuron? if so what type? And the locus is the entire CNS? or just in the straitum (or we dont know)? I wish i could afford to buys this article, does any one want to sum up the rest for me? And if the mice they (drugged or genetherap"ied" or engineederd?) have a problem preforming the task (in effect similar to parkinsons) then (gene therapy or drugs?) could be developed/executed to to prefom the reverse function as that which was engineered in/for the mice in effect removing walking gait issues in parkinsonian mice?
Reply | Report Abuse | Link to thisOH MY GOSH... another anatomic neurological basis for behavior... or in this case a model in Mice for a common neurological disorder.
Reply | Report Abuse | Link to thisFifty years hence the notion of humans as possesing supernatural "souls" and unfettered "free will" will be as quaint as thinking of dyslexics as lazy or ADD children as defiant.
Sir Francis Crick was... entirely correct, there are neurological correlates of consciousness and our brains are in fact, our minds.