Telomerase reverses aging process
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By Ewen Callaway
Premature aging can be reversed by reactivating an enzyme that protects the tips of chromosomes, a study in mice suggests.
Mice engineered to lack the enzyme, called telomerase, become prematurely decrepit. But they bounced back to health when the enzyme was replaced. The finding, published online November 28 in Nature, hints that some disorders characterized by early aging could be treated by boosting telomerase activity. (Scientific American is part of Nature Publishing Group.)
It also offers the possibility that normal human aging could be slowed by reawakening the enzyme in cells where it has stopped working, says Ronald DePinho, a cancer geneticist at the Dana-Farber Cancer Institute and Harvard Medical School in Boston, Massachusetts, who led the new study. "This has implications for thinking about telomerase as a serious anti-aging intervention."
Other scientists, however, point out that mice lacking telomerase are a poor stand-in for the normal aging process. Moreover, ramping up telomerase in humans could potentially encourage the growth of tumors.
Eternal youth
After its discovery in the 1980s, telomerase gained a reputation as a fountain of youth. Chromosomes have caps of repetitive DNA called telomeres at their ends. Every time cells divide, their telomeres shorten, which eventually prompts them to stop dividing and die. Telomerase prevents this decline in some kinds of cells, including stem cells, by lengthening telomeres, and the hope was that activating the enzyme could slow cellular aging.
Two decades on, researchers are realizing that telomerase's role in aging is far more nuanced than first thought. Some studies have uncovered an association between short telomeres and early death, whereas others have failed to back up this link. People with rare diseases characterized by shortened telomeres or telomerase mutations seem to age prematurely, although some tissues are more affected than others.
When mice are engineered to lack telomerase completely, their telomeres progressively shorten over several generations. These animals age much faster than normal mice--they are barely fertile and suffer from age-related conditions such as osteoporosis, diabetes and neurodegeneration. They also die young. "If you look at all those data together, you walk away with the idea that the loss of telomerase could be a very important instigator of the aging process," says DePinho.
To find out if these dramatic effects are reversible, DePinho's team engineered mice such that the inactivated telomerase could be switched back on by feeding the mice a chemical called 4-OHT. The researchers allowed the mice to grow to adulthood without the enzyme, then reactivated it for a month. They assessed the health of the mice another month later.
"What really caught us by surprise was the dramatic reversal of the effects we saw in these animals," says DePinho. He describes the outcome as "a near 'Ponce de Leon' effect" -- a reference to the Spanish explorer Juan Ponce de Leon, who went in search of the mythical Fountain of Youth. Shriveled testes grew back to normal and the animals regained their fertility. Other organs, such as the spleen, liver and intestines, recuperated from their degenerated state.
The one-month pulse of telomerase also reversed effects of aging in the brain. Mice with restored telomerase activity had noticeably larger brains than animals still lacking the enzyme, and neural progenitor cells, which produce new neurons and supporting brain cells, started working again.
"It gives us a sense that there's a point of return for age-associated disorders," says DePinho. Drugs that ramp up telomerase activity are worth pursuing as a potential treatment for rare disorders characterized by premature aging, he says, and perhaps even for more common age-related conditions.
Cancer link
The downside is that telomerase is often mutated in human cancers, and seems to help existing tumors grow faster. But DePinho argues that telomerase should prevent healthy cells from becoming cancerous in the first place by preventing DNA damage.
David Sinclair, a molecular biologist at Harvard Medical School in Boston, agrees there is evidence that activating telomerase might prevent tumors. If the treatment can be made safe, he adds, "it could lead to breakthroughs in restoring organ function in the elderly and treating a variety of diseases of aging."
Other researchers are less confident that telomerase can be safely harnessed. "Telomere rejuvenation is potentially very dangerous unless you make sure that it does not stimulate cancer," says David Harrison, who researches aging at the Jackson Laboratory in Bar Harbor, Maine.
Harrison also questions whether mice lacking telomerase are a good model for human aging. "They are not studying normal aging, but aging in mice made grossly abnormal," he says. Tom Kirkwood, who directs the Institute for Ageing and Health at Newcastle University, UK, agrees, pointing out that telomere erosion "is surely not the only, or even dominant, cause" of aging in humans.
DePinho says he recognizes that there is more to aging than shortened telomeres, particularly late in life, but argues that telomerase therapy could one day be combined with other therapies that target the biochemical pathways of aging. "This may be one of several things you need to do in order to extend lifespan and extend healthy living," he says.
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41 Comments
Add CommentThis study is going to piss off Socialists around the globe.....
Reply | Report Abuse | Link to this@nogod, why? What's more, why do you feel the need to make this political?
Reply | Report Abuse | Link to thisThe average lifespan of a lab mouse is two years. Couldn't the researchers test this hypothesis on normally aged mice instead of mice genetically engineered to lack telomerase. It's not like they have to wait much longer. Or use other short lived specimens like fruit flies or worms. The only discovery in this experiment is that mice bred without telomerase have an increase in lifespan when the enzyme is administered.
Reply | Report Abuse | Link to this@Scico, "The only discovery in this experiment is that mice bred without telomerase have an increase in lifespan when the enzyme is administered." You should consider for a moment that the reason you don't get this is because you don't understand the science rather than the scientists not understanding the science. The study was an attempt to understand the roll of telomerase in aging. It seems to me that it is much easier to understand if you take it away rather than leaving it. The effect of adding more telomerase to a healthy animal is a completely different issue. So the short answer to why they didn't try to do this experiment your way is because they weren't trying to prove your hypothesis.
Reply | Report Abuse | Link to thisI understand the science just fine and I would like to see normal mice administered with telomerase to see if they live longer than a normal mouse who has not received the enzyme (which i'm sure Scico is referring to). What ur referring to would be like saying a mouse that was without iron in its blood who received an iron supplement and lived longer could be considered a rejuvinator and obviously it would live longer but no longer than a mouse that was with the iron in its blood to begin with.
Reply | Report Abuse | Link to thisAlso this study has been done before and we all already knew what the study has shown..why not try something new like injecting the enzyme to extend the life of a normal mouse and keep the telomers "stocked up" so to speak..that would be a much more cutting edge story. Pretty sure this story has been done in a BBC documentary perhaps 'How To Build A Human 4of4 Forever Young' or perhaps one of the DNA docs..didn't feel like going through my collection to find out.
Also almost all health science is the reductionist type science because its all based on variables and you need to take out all and just measure one hence why they (scientists) are having a difficult time with nutrition because food has so many variables (nutrients) in them. But anyways yeah sorry if i'm all over the board..i may have A.D.D. :D
First of all I have a BSc. in biology so I do understand the science. Second of all this research will only benefit humans born without telomerase which I don't think exist in the population. There are too many variables and third factors in this study. This experiment should be conducted on normal, aged mice with age related disease like arthritis or brain degeneration. If the administration of telomerase reverts them to healthy adolescents then I would be more convinced.
Reply | Report Abuse | Link to thisWe look forward to your results.
Reply | Report Abuse | Link to thisI agree with Scico and Loubarouba, the only conclusion of this experiment is that; "re-introducing telomeres do reverse the effects of telomerase deficiency", it doesn't answer the question whether a normal aging can be reversed by adding more telomerase.
Reply | Report Abuse | Link to thisIf normal aging is caused by other factor rather than just a shortened telomerase; then adding more telomerase will not increase a person's lifespan, the analogy is like malnutrition; if a person is malnourished then adding only IRON (or perhaps Vitamin-A) to his diet won't cure malnutritions but instead could've killed him (overdose of Vitamin A can have a negative side effect), the research just isn't designed to prove that adding telomerase can indeed increase lifespan (of normal mice).
Yeah, the logic on this is indisputable. Knock out an enzyme which is required for normal function and then restore its activity. Clear and convincing evidence that telomerase will provide the font of youth... Or not.
Reply | Report Abuse | Link to thisGuess what, if you knock out any of thousands of genes you will see similar detriment effects on health. And what's more, if you rescue gene function in a knock out model, the effects can often be reversed (obviously, this will depend on the gene and when its function is restored). Does this mean that over-expression of these genes will enhance the life span? No.
Also, this idea that the shortening of telomeres is the only cause of aging is total bunk. Anyone with a second rate education in genetics can tell you that.
My God, Sci Am. I really expect a more nuanced coverage from you guys.
"What ur referring to would be like saying a mouse that was without iron in its blood who received an iron supplement and lived longer could be considered a rejuvinator and obviously it would live longer but no longer than a mouse that was with the iron in its blood to begin with." false analogy. First, by knocking out telomerase it was demonstrated that telomerase is linked with a broad spectrum of diseases related to aging. Then it was demonstrated that "repairing" the telomerase system not only stopped the advance of the disease but reversed it. This is significant as it suggests a target for managing age related disease specifically where a reduction in telomerase is implicated. Based on the results of the experiment the researchers are hypothesising that boosting telomerase may reduce age related disease in people but proving that wasn't the purpose of the study which commenters here seem to be stuck on. The people here claiming that this hypothesis is not valid because the experiment didn't prove it clearly do not understand what a hypothesis is or by extension, how science works.
Reply | Report Abuse | Link to thisDoes this mean we should all start taking Testobol 4-OHT Ether if we want to test this hypothesis on ourselves? Or is 4-OHT's effects most likely specific to mice?
Reply | Report Abuse | Link to thisIn science we question and debate the results. We don't follow like sheep. Many accepted theories have been disproven. We don't find answers only more questions. That's how science works.
Reply | Report Abuse | Link to thisSorry, Robert, but I believe you are taking an overly liberal position on this topic. How much evidence is there that reductions in telomerase cause aging in any human population? If there were evidence of such an effect, then this study would be far more interesting. But, at the current time, I do not know of any study which has provided direct evidence demonstrating that telomerase reductions cause aging. Hence, this paper really provides little more than fodder for a relatively weak hypothesis: namely, that the shortening of telomeres is the primary cause of human aging.
Reply | Report Abuse | Link to thisThe most legitimate way to look at this finding is with a skeptical eye. KO studies are useful and can provide a wealth of information. But, they also suffer from the rather problematic side effect of being highly artificial. As has been suggested by many other commenters, a KO model which is deficient in any of a number of genes can lead to pathology. This pathology can often be restored by rescuing the function of that gene. But this only provides tangential evidence as to the normal function of the gene of interest.
In particular, Sci Am's coverage of this study has hardly been enlightening. The title says it all: "telomerase reverses aging process" is possibly the most ridiculous and least supported claim which could be made based upon this study. Clearly, if nothing else, we can all agree on this.
I should clarify. Telomerase has been implicated in human disease. But, so far as I know, it has not been directly demonstrated to play a role in normal aging. Hence, I should not have said "any human population".
Reply | Report Abuse | Link to thisFirst of all, he's correct (because socialist, especially the watermelon variety, positively hate other people).
Reply | Report Abuse | Link to thisSecondly, Scientific American is basically a political magazine anyway, albeit, one that specializes in science.
-Ken
kenstech.com
Get over yourself. They never said telemere erosion was the ONLY cause of aging. In fact, the article made pains to make that point.
Reply | Report Abuse | Link to thisken
kenstech.com
There is an island in the South Pacific where most of the population reaches 100+. They live healthy productive lives until they die. Why is no one studying them?
Reply | Report Abuse | Link to thisWhat is being claimed is not new. The proper experiment should have been the effect of telomerase on stem cells, embryonic or otherwise, then watch for mitotic activity rate and consequent/subsequent cancerogenesis. Dr.d
Reply | Report Abuse | Link to thisThere are small groups of population's around the word that live both longer and shorter lifespans,but the reasons why involve hundreds sometimes thousands of genes,but what works for some doesn't work for others.But clearly finding a safe way to repair telomerase would in the short term increase lifespans,but the quality of those lives is what is important.What good is a longer life if it's in poverty,strife,and misery.
Reply | Report Abuse | Link to thisMoreover, what would the general effect of longer life be on the already overpopulated planet - runaway population growth, resource depletion and global warming? Of course we'd probably limit extended life to those who could afford it, right?
Reply | Report Abuse | Link to thisWhy not evaluate if changes in telomerase is behind the apparant accelerated aging of clones as I remember reading about Dolly the sheep?
Reply | Report Abuse | Link to thisTelomerase enhancement will probably work, in theory. However, don't forget cancer. Extending life will increase the chances of cancer and there's no escaping it. Cancer is a "normal" biological process, inevitable.
Reply | Report Abuse | Link to this"Watermelon variety"? As opposed to corn cob variety? What a silly thing to say! Then there is the ignorant and plainly false statement that socialists hate anyone at all. You are mistaking nationalists for socialists. The huge amount of hate in your post renders any point you try to make entirely absurd.
Reply | Report Abuse | Link to thisTry debating the science in the article. That is what the forums are for. Unless you admit inferiority and the inability to think.
PS. I'm a fascist not a socialist so don't even waste time going there with your feeble rant.
A life of misery is generally better than death. Donald Trump lost everything at one point. No one gathered around him chanting "death is better". I find jtdwyer's resonse to your post much more logical.
Reply | Report Abuse | Link to thisFor those suffering from premature aging disorders this is a great study. For the rest of us this kind of study needs to be done on naturally aged mice to see the impact. These are 2 different issues that are only partly related.
Reply | Report Abuse | Link to thisI have a disease that is essentially an over-reproduction of skin cells. The telomeres have been shown to decline in their function in replication due to ageing. Therefore, my chances of skin cancer are elevated. This research is valuable for treating present disorders, but dubious for prolonging life in otherwise healthy people.
Reply | Report Abuse | Link to thisClearly you didn't read my post. Most of it was directed at another commenter. I clearly state that Sci Am's coverage is irresponsible because of how they portray this finding. In particular, they seek to bias readers views by presenting a title which is unequivocally false.
Reply | Report Abuse | Link to thisThere is significant evidence that short telomeres cause premature death in the bay scallop, Argopecten irradians as reported in the Journal of Shellfish Research. Telomere studies are numerous. Enlarging telomeres seems a logical conclusion.
Reply | Report Abuse | Link to thisWe are the FIRST with a YOGURT bacteria, Lactobacillus family, that has the PROPRIETARY ability to PRODUCE AND EXCRETE ACTIVE TELOMERASE ENZYME (hTERT) *AND* produce its RNA compliment (TERC) via bacteria and TRANSDUCE the ACTIVE Telomerase protein INTO normal human mammalian cells via a NUTRIENT delivery system called a PTD.
Reply | Report Abuse | Link to thisThis Study published in NATURE, only serves to corroborate my research of 27 years and then the DEVELOPMENT done in the year 2002, where I SUCCEEDED in delivering the first ACTIVE TELOMERASE ENZYME TO MYSELF and to TWO BANKERS from England and compared the cells (mucosa from the mouth) to show ALL THE CHARACTERISTICS OF YOUTH in ONE HOUR via PHOTO EVIDENCE. I was the FIRST to show TELOMERASE REJUVENATION EVIDENCE, using a FISH test (Fluorescent In Situ Hybridization) of the telomeres BEFORE AND ONE HOUR AFTER my product. Back then, the Corporation that had telomeric fluorescent probes was VYSIS Corporation, which was afterwards bout out by Abbot Laboratories. My photos are actually online, since the year 2002 and my contract with the Bankers for a TEST only, (successfully I might add) dates back to the year 2000, giving me PRIORITY to my patent. By this present study, I can see, that my competition is clearly behind me by about TEN YEARS and they haven't even developed a viable system of PRODUCTION of the ACTIVE TELOMERASE enzyme, putting it in some kind of a DELIVERY system, DELIVERING THE ENZYME to the human body to ALL CELLS of the Human body EVENLY, giving it shelf life, (cut an apple in half and you'll see enzymes DEGRADE IN MINUTES), nor a system of allowing a large protein such as Telomerase to ENTER mammalian cells such as in our system of TRANSDUCTION to deliver the pure protein which already has a nuclear localization signal (telomerase is a riboNUCLEOprotein), VERIFY its efficacy in repairing TELOMERES, such as seeing the effects of full cellular rejuvenation on human cells in vitro and vivo such as the return of the production of TUBULIN in ONE HOUR allowing the cells to become ROUND AGAIN from old-senescent and irregularly sided (like an umbrella without and WITH all the spokes emanating radially from the nucleus IN ONE HOUR), or such as seeing HAIR COLOR and HAIR return by using it topically as a cosmetic where two experts in medicine with gray hair since 15 had their hair return to COLOR in EIGHTEEN DAYS, PHOTOS AT MY WEBSITE igrowhair.com
I applaud this Co-Verification of my work. It should bring me more investors and Billions in sales of my Cosmetics. I toast Telomerase to you.
In regards to all the SCARE TACTICS saying that Telomerase could cause cancer: The answer is NO, dammit! EVEN THIS VERY TEST in mice PROVES IT, since when they turned-on the production of telomerase, the mice DID NOT BEGIN TO DEVELOP CANCER! SEE! EVEN THIS VERY TEST PROVES IT, as ALL THE OTHER TESTS have proven that telomerase IS NOT CARCINOGENIC AT ALL! Or all the mice would have died of cancer and even me would be dead of cancer since the year 2000 when I took my first telomerase. You can read the SAFETY STUDIES done on Telomerase by M.I.T. and Duke University
Reply | Report Abuse | Link to thishttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413782/
Where Telomerase is deemed SAFE.
Just because a cancer cell is a cell gone wild and in an undifferentiated state without its P-53 checkpoint gene, producing ALL THE CHEMICALS IN ITS ENTIRE DNA, including a CALCIUM IGLOO and TELOMERASE, it doesn't mean that CALCIUM or TELOMERASE can INDUCE a normal cell to become cancerous. And realize that Cancer cells have TELOMERASE IN STOCK and giving them more telomerase would be redundant. HOWEVER giving telomerase to the IMMUNE SYSTEM cells (T-Killers) would be giving the immune system cells the SAME ADVANTAGE of FAST DIVISION as CANCER CELLS HAVE, and create a CLONED ARMY OF IMMUNE CELLS AND DESTROY THE CANCER.
FURTHERMORE, the cells provided by Clontech, "The Infinity Line of Telomerase Immortalized Cells" where they have cells now dividing to 680 TIMES or more!, ARE NOT TURNING CANCEROUS, for the contrary they show STILL HEALTHY AND NORMAL AND YOUNG EVEN AFTER 680 POPULATION DOUBLINGS ***WITHOUT*** TURNING INTO CANCER CELLS!
FURTHER, IF BABIES are essentially YOUR OWN OLD CELLS rejuvenated via the sperm's production of TELOMERASE, then ALL BABIES WOULD DIE OF CANCER as they came out, if TELOMERASE was carcinogenic.
FURTHERMORE, look at a teenager, producing copious amounts of TELOMERASE via their large thymus gland, producing telomerase-producing T-Cells, look at how HEALTHY they are with a POWERFUL IMMUNE SYSTEM, versus old and senescent, people, when their thymus all but disappears by the age of 45 and no production of T-Cells and no production of Telomerase, look at how old they look and their immune system sucks and THEN THEY GET CANCER!
Well, it only PROVES the fact THAT NO TELOMERASE LEADS TO CANCER.
AND TELOMERASE REJUVENATES THE IMMUNE SYSTEM TO FIGHT CANCER!
So STOP SCARING PEOPLE with the word CANCER and Telomerase in the same writings and publications, to STOP anyone with FEAR, so YOU get to be the one developing PRODUCTS.IT WON'T WORK! Telomerase IS VITAL!
In regards to all the SCARE TACTICS saying that Telomerase could cause cancer: The answer is NO, dammit! EVEN THIS VERY TEST in mice PROVES IT, since when they turned-on the production of telomerase, the mice DID NOT BEGIN TO DEVELOP CANCER! SEE! EVEN THIS VERY TEST PROVES IT, as ALL THE OTHER TESTS have proven that telomerase IS NOT CARCINOGENIC AT ALL! Or all the mice would have died of cancer and even me would be dead of cancer since the year 2000 when I took my first telomerase. You can read the SAFETY STUDIES done on Telomerase by M.I.T. and Duke University
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413782/
Where Telomerase is deemed SAFE.
Just because a cancer cell is a cell gone wild and in an undifferentiated state without its P-53 checkpoint gene, producing ALL THE CHEMICALS IN ITS ENTIRE DNA, including a CALCIUM IGLOO and TELOMERASE, it doesn't mean that CALCIUM or TELOMERASE can INDUCE a normal cell to become cancerous. And realize that Cancer cells have TELOMERASE IN STOCK and giving them more telomerase would be redundant. HOWEVER giving telomerase to the IMMUNE SYSTEM cells (T-Killers) would be giving the immune system cells the SAME ADVANTAGE of FAST DIVISION as CANCER CELLS HAVE, and create a CLONED ARMY OF IMMUNE CELLS AND DESTROY THE CANCER.
FURTHERMORE, the cells provided by Clontech, "The Infinity Line of Telomerase Immortalized Cells" where they have cells now dividing to 680 TIMES or more!, ARE NOT TURNING CANCEROUS, for the contrary they show STILL HEALTHY AND NORMAL AND YOUNG EVEN AFTER 680 POPULATION DOUBLINGS ***WITHOUT*** TURNING INTO CANCER CELLS! 
FURTHER, IF BABIES are essentially YOUR OWN OLD CELLS rejuvenated via the sperm's production of TELOMERASE, then ALL BABIES WOULD DIE OF CANCER as they came out, if TELOMERASE was carcinogenic.
FURTHERMORE, look at a teenager, producing copious amounts of TELOMERASE via their large thymus gland, producing telomerase-producing T-Cells, look at how HEALTHY they are with a POWERFUL IMMUNE SYSTEM, versus old and senescent, people, when their thymus all but disappears by the age of 45 and no production of T-Cells and no production of Telomerase, look at how old they look and their immune system sucks and THEN THEY GET CANCER!
Well, it only PROVES the fact THAT NO TELOMERASE LEADS TO CANCER.
AND TELOMERASE REJUVENATES THE IMMUNE SYSTEM TO FIGHT CANCER!
So STOP SCARING PEOPLE with the word CANCER and Telomerase in the same writings and publications, to STOP anyone with FEAR, so YOU get to be the one developing PRODUCTS.IT WON'T WORK! Telomerase IS VITAL!
Reply | Report Abuse | Link to thisIn regards to all the SCARE TACTICS saying that Telomerase could cause cancer: The answer is NO, dammit! EVEN THIS VERY TEST in mice PROVES IT, since when they turned-on the production of telomerase, the mice DID NOT BEGIN TO DEVELOP CANCER! SEE! EVEN THIS VERY TEST PROVES IT, as ALL THE OTHER TESTS have proven that telomerase IS NOT CARCINOGENIC AT ALL! Or all the mice would have died of cancer and even me would be dead of cancer since the year 2000 when I took my first telomerase. You can read the SAFETY STUDIES done on Telomerase by M.I.T. and Duke University
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413782/
Where Telomerase is deemed SAFE.
Just because a cancer cell is a cell gone wild and in an undifferentiated state without its P-53 checkpoint gene, producing ALL THE CHEMICALS IN ITS ENTIRE DNA, including a CALCIUM IGLOO and TELOMERASE, it doesn't mean that CALCIUM or TELOMERASE can INDUCE a normal cell to become cancerous. And realize that Cancer cells have TELOMERASE IN STOCK and giving them more telomerase would be redundant. HOWEVER giving telomerase to the IMMUNE SYSTEM cells (T-Killers) would be giving the immune system cells the SAME ADVANTAGE of FAST DIVISION as CANCER CELLS HAVE, and create a CLONED ARMY OF IMMUNE CELLS AND DESTROY THE CANCER.
FURTHERMORE, the cells provided by Clontech, "The Infinity Line of Telomerase Immortalized Cells" where they have cells now dividing to 680 TIMES or more!, ARE NOT TURNING CANCEROUS, for the contrary they show STILL HEALTHY AND NORMAL AND YOUNG EVEN AFTER 680 POPULATION DOUBLINGS ***WITHOUT*** TURNING INTO CANCER CELLS! 
FURTHER, IF BABIES are essentially YOUR OWN OLD CELLS rejuvenated via the sperm's production of TELOMERASE, then ALL BABIES WOULD DIE OF CANCER as they came out, if TELOMERASE was carcinogenic.
FURTHERMORE, look at a teenager, producing copious amounts of TELOMERASE via their large thymus gland, producing telomerase-producing T-Cells, look at how HEALTHY they are with a POWERFUL IMMUNE SYSTEM, versus old and senescent, people, when their thymus all but disappears by the age of 45 and no production of T-Cells and no production of Telomerase, look at how old they look and their immune system sucks and THEN THEY GET CANCER!
Well, it only PROVES the fact THAT NO TELOMERASE LEADS TO CANCER.
AND TELOMERASE REJUVENATES THE IMMUNE SYSTEM TO FIGHT CANCER!
So STOP SCARING PEOPLE with the word CANCER and Telomerase in the same writings and publications, to STOP anyone with FEAR, so YOU get to be the one developing PRODUCTS.IT WON'T WORK! Telomerase IS VITAL!
Reply | Report Abuse | Link to thisWe are the FIRST with a YOGURT bacteria, Lactobacillus family, that has the PROPRIETARY ability to PRODUCE AND EXCRETE ACTIVE TELOMERASE ENZYME (hTERT) *AND* produce its RNA compliment (TERC) via bacteria and TRANSDUCE the ACTIVE Telomerase protein INTO normal human mammalian cells via a NUTRIENT delivery system called a PTD.
Reply | Report Abuse | Link to thisThis Study published in NATURE, only serves to corroborate my research of 27 years and then the DEVELOPMENT done in the year 2002, where I SUCCEEDED in delivering the first ACTIVE TELOMERASE ENZYME TO MYSELF and to TWO BANKERS from England and compared the cells (mucosa from the mouth) to show ALL THE CHARACTERISTICS OF YOUTH in ONE HOUR via PHOTO EVIDENCE. I was the FIRST to show TELOMERASE REJUVENATION EVIDENCE, using a FISH test (Fluorescent In Situ Hybridization) of the telomeres BEFORE AND ONE HOUR AFTER my product. Back then, the Corporation that had telomeric fluorescent probes was VYSIS Corporation, which was afterwards bout out by Abbot Laboratories. My photos are actually online, since the year 2002 and my contract with the Bankers for a TEST only, (successfully I might add) dates back to the year 2000, giving me PRIORITY to my patent. By this present study, I can see, that my competition is clearly behind me by about TEN YEARS and they haven't even developed a viable system of PRODUCTION of the ACTIVE TELOMERASE enzyme, putting it in some kind of a DELIVERY system, DELIVERING THE ENZYME to the human body to ALL CELLS of the Human body EVENLY, giving it shelf life, (cut an apple in half and you'll see enzymes DEGRADE IN MINUTES), nor a system of allowing a large protein such as Telomerase to ENTER mammalian cells such as in our system of TRANSDUCTION to deliver the pure protein which already has a nuclear localization signal (telomerase is a riboNUCLEOprotein), VERIFY its efficacy in repairing TELOMERES, such as seeing the effects of full cellular rejuvenation on human cells in vitro and vivo such as the return of the production of TUBULIN in ONE HOUR allowing the cells to become ROUND AGAIN from old-senescent and irregularly sided (like an umbrella without and WITH all the spokes emanating radially from the nucleus IN ONE HOUR), or such as seeing HAIR COLOR and HAIR return by using it topically as a cosmetic where two experts in medicine with gray hair since 15 had their hair return to COLOR in EIGHTEEN DAYS, PHOTOS AT MY WEBSITE igrowhair.com
I applaud this Co-Verification of my work. It should bring me more investors and Billions in sales of my Cosmetics. I toast Telomerase to you.
I did not say telomerase causes cancer. Age causes cancer. As we get older the probability of damage to DNA increases from a variety of causes. If telomerase treatments are effective in extending maximum age, we will face an increased risk of cancer from all causes.
Reply | Report Abuse | Link to thisThere you go again, scaring people again about "cancer", so they don't do telomerase. Your "new" take is that if telomerase made you live longer, there would be more chances during a longer time period, to get cancer? Again, the answer is no. If you're a teenager, (TELOMERASE RETURNS YOU TO BEING A TEENAGER), versus an old man, the chances are that the teenager immune system with a fast metabolism and the huge production of T-Cells (T-Killer cells kill cancer cells with a harpoon filled with "SOAP" that injects the "soap" into the cancer cells and LYSES the cell wall of the cancer cells, (dissolves the cell wall), have you ever seen a T-Killer in action? I HAVE! Now, being a teenager, you have a much higher amount of T-Killer and a STRONG immune system, ABLE TO KILL CANCER CELLS as fast as the are formed. However, by choosing to be TELOMERASE DEFICIENT, OLD AND SENESCENT, you no longer will have the same ability. You don't realize that Telomerase not only makes you live longer, it ALSO MAKES YOU YOUNGER, INCLUDING YOUR IMMUNE SYSTEM, (see UCLA uncorks fountain of youth for HIV fighting cells), YOUR FERTILITY COMES BACK (just like the mice in this study), 50 YEAR OLD LADIES GOT THEIR PERIODS BACK, MACULAR DEGENERATION ELIMINATED IN THREE DAYS, KIDNEY FAILURE: "FROM 3cc's to a FULL QUART OF URINE ***IN ONE HOUR!!!***, 2 DIABETICS WENT INTO INSULIN SHOCK ONE WEEK AFTER TELOMERASE BECAUSE THEY GAVE THEMSELVES THE SAME AMOUNT OF INSULIN WHEN THEIR PANCREAS HAD RETURNED TO NORMAL AND THEY NO LONGER NEEDED THE INSULIN, FOUR TOTALLY JAUNDICED LADIES HAD THE COLOR RETURNED TO THEIR FACES AND HANDS IN ONE HOUR RIGHT IN FRONT OF THEIR FAMILIES WATCHING, ONE TOTALLY INCOHERENT WHEELCHAIR BOUND DEMENTIA LADY IN ONE WEEK WAS TOTALLY AMBULANT AND WALKED UP THE STAIRS TO EVERYONE'S AMAZEMENT AND THEN SHE STARTED TALKING ABOUT REAL ESTATE WITH ME SHE WAS A BRILLIANT LADY! THREE BREAST CANCER PATIENTS, WELL, YOU GET THE PICTURE. BUT I MAKE NO CLAIMS, OF COURSE. NOW, IF YOU WANT TO TAKE YOUR CHANCES WITH CANCER, OR AGING, THAT'S UP TO YOU. YOU TAKE VITAMIN C TO KEEP YOU FROM GETTING SCURVY, WELL, YOU SHOULD TAKE TELOMERASE TO KEEP YOU FROM GETTING AGING. And again, a longer life WHILE ALSO BEING A HEALTHY TEENAGER, is much better than a shorter life being an old man dying of a SLOW AGING DEATH without telomerase. So, what will it be? Telomerase? or Aging? CHOOSE TELOMERASE! AhhhDDuuuhh!!!
Reply | Report Abuse | Link to thisDear Joe Fox Don't rant and rave so much if you want people to take you seriously. And your web site is juvenile at best, seemingly foreign at worst. Too many capitalized words. Telomere degradation will kill me prematurely, most likely. But I am hesitant to contact you because you seem like a snake-oil salesman. Get professional help for your web site and try to appear like a scientist. For starters...igrowhair.com is a stupid name for a site that promises a revolutionary cure for ageing. Some of us don't give a shit about our appearance.
Reply | Report Abuse | Link to thisWe are the FIRST with a YOGURT bacteria, Lactobacillus family, that has the PROPRIETARY ability to PRODUCE AND EXCRETE ACTIVE TELOMERASE ENZYME (hTERT) *AND* produce its RNA compliment (TERC) via bacteria and TRANSDUCE the ACTIVE Telomerase protein INTO normal human mammalian cells via a NUTRIENT delivery system called a PTD.
Reply | Report Abuse | Link to thisThis Study published in NATURE, only serves to corroborate my research of 27 years and then the DEVELOPMENT done in the year 2002, where I SUCCEEDED in delivering the first ACTIVE TELOMERASE ENZYME TO MYSELF and to TWO BANKERS from England and compared the cells (mucosa from the mouth) to show ALL THE CHARACTERISTICS OF YOUTH in ONE HOUR via PHOTO EVIDENCE. I was the FIRST to show TELOMERASE REJUVENATION EVIDENCE, using a FISH test (Fluorescent In Situ Hybridization) of the telomeres BEFORE AND ONE HOUR AFTER my product. Back then, the Corporation that had telomeric fluorescent probes was VYSIS Corporation, which was afterwards bout out by Abbot Laboratories. My photos are actually online, since the year 2002 and my contract with the Bankers for a TEST only, (successfully I might add) dates back to the year 2000, giving me PRIORITY to my patent. By this present study, I can see, that my competition is clearly behind me by about TEN YEARS and they haven't even developed a viable system of PRODUCTION of the ACTIVE TELOMERASE enzyme, putting it in some kind of a DELIVERY system, DELIVERING THE ENZYME to the human body to ALL CELLS of the Human body EVENLY, giving it shelf life, (cut an apple in half and you'll see enzymes DEGRADE IN MINUTES), nor a system of allowing a large protein such as Telomerase to ENTER mammalian cells such as in our system of TRANSDUCTION to deliver the pure protein which already has a nuclear localization signal (telomerase is a riboNUCLEOprotein), VERIFY its efficacy in repairing TELOMERES, such as seeing the effects of full cellular rejuvenation on human cells in vitro and vivo such as the return of the production of TUBULIN in ONE HOUR allowing the cells to become ROUND AGAIN from old-senescent and irregularly sided (like an umbrella without and WITH all the spokes emanating radially from the nucleus IN ONE HOUR), or such as seeing HAIR COLOR and HAIR return by using it topically as a cosmetic where two experts in medicine with gray hair since 15 had their hair return to COLOR in EIGHTEEN DAYS, PHOTOS AT MY WEBSITE igrowhair.com
The website will be updated soon with FLASH. For now it is just the necessary information and links, to become an investor and obtain free bottles!
I think science has produced lots of good ideas around anti-aging. One that I'm very fond of is Protandim, which I take and has worked wonders. Protandim (not its ingredients) has been studied (and is being studied) by universities. The production of SOD, Catalase and Glutathione have also proven to increase the age of mice, and among other very beneficial things. See www.studynrf2.com, for an ABC Primetime video on Protandim that talks about this.
Reply | Report Abuse | Link to thisigrowhairdotcom is now in jail in Miami Dade County for fraud. It's not good to take money from investors and spend it on yourself. If this guy had anything, which is highly doubtful, no one will ever believe anything he says again.
Reply | Report Abuse | Link to thisi agree with the poster that said why dont they do the same experiment on mice that have aged naturally! and then publish the results! dont even tell me for one minute that they have not done this! because they have and not published the results! because its more than likely had insignificant effects! 99% of scientific research is done in secret and never published! that telomerase drug tg what ever its called that is being sold for silly money under the illusion its going to make you stay young is a disgrace! they dont even know if telomerase is expressed in normal cells go to gerons web sight the people who make that drug and thats what they say! taking something away from an animal model and then reinstating it does not represent what happens in natural aging! its like depriving mice with essential vitamins and then readministering the vitamins and saying look at how vitamins slow aging and deseise.
Reply | Report Abuse | Link to thisI just want to say that Robert Schmidt's comments are completely correct.
Reply | Report Abuse | Link to thisThe experiments show that telomerase is very important to the ageing process.
Hopefully there will be more experiments and the telomerase enzyme will make it possible to live for a very long time.