Sandy Allen—the world's tallest woman, according to Guinness World Records—died on Wednesday (August 13) in the Indiana nursing home where she lived, the Associated Press reports. Allen was 53 years old and stood seven feet, seven inches (2.3 meters) tall—a full inch taller than Chinese basketball star Yao Ming.

As a child, Allen developed a tumor in her pituitary gland—a pea-size structure at the base of the brain that secretes several hormones that are key to the body's function, including human growth hormone. As a result of the tumor, she developed gigantism—her bones grew excessively, causing, among other things, her prodigious height.

With the large proportions came a host of health issues. Although the cause of Allen's death is unknown, she suffered from diabetes, frequent infections, breathing difficulties and kidney failure. She spent much of her later years confined to a wheelchair.

After a career largely devoted to educating children about accepting others' differences, she returned to Indiana and eventually lived in Heritage House Convalescent Center in her hometown of Shelbyville. It's the very same nursing home where Guinness's oldest living woman, 115-year-old Edna Parker, resides.

ScientificAmerican.com rang up Daniel Kelley, medical director of the Neuro-Endocrine Tumor Center at Saint John's Health Center in Santa Monica, Calif., to find out more about Allen's condition.

Is gigantism a normal consequence of pituitary gland tumors?
I don't know her story at all, but it certainly sounds to me like she was an acromegalic giant. That's the only way it happens--if they had a pituitary tumor. The tumor is making excess growth hormone--it's a growth hormone-secreting adenoma that developed prior to her bone growth stopping, when she was still growing. If someone has excess growth hormone, they become excessively tall and become an acromegalic giant.

How common are these pituitary tumors?
About one in 20 people will have an abnormality in their pituitary gland…. And based on some recent demographic studies, about one in 1,000 people probably have a symptomatic pituitary adenoma [the tumor Allen had]. So, a subset of those--maybe 10 percent would have acromegaly, but it's hard to know.

According to the AP story on her death, Allen said she had her growth surgically stopped in her early 20s. How would doctors do that?
She probably had the tumor removed. The standard treatment for someone who has a pituitary tumor is to remove it through endonasal surgery [in which surgeons go through the nose to cut out the tumor]. The goal is remove all the adenoma to protect the normal pituitary gland.

The other treatment options for someone with acromegaly or gigantism, as she had, is radiotherapy--radiosurgery or stereotactic radiotherapy—that is, giving focused radiation to the pituitary tumor to avoid damage to surrounding structures.

Then the third are medications that block the effects of growth hormone or block the actions of insulin growth factor 1. That's what's called the "second messenger of growth hormone." So, when the growth hormone is released by the pituitary, the liver makes IGF1, and that's how you get the effects of growth hormone--through IGF1.

For people with acromegaly, aside from the gigantism, are there other frequent health defects?
The problem with acromegaly is really quite severe. It's a benign adenoma 99.9 percent of the time, but it can cause health problems including hypertension [high blood pressure], diabetes, obstructive sleep apnea [when breathing stops during sleep], carpal tunnel syndrome [pain, numbness or a tingling sensation in the hand or fingers]. So people with untreated acromegaly gigantism, in addition to the growth problems, they can have premature death because of the other associated problems. They get organomegaly--so all their organs get big, too--so they have a higher incidence of heart disease. Then you couple that with hypertension and diabetes and you can imagine they don't live very long.

3 Comments

1. 1. Minnie 10:09 AM 8/14/08

   Neil Finn, lead singer/songwriter of Crowded House wrote the song "Hello Sandy Allen" while still with Split Enz after meeting Sandy at the taping of a talk show in NY. The song was released in 1983.
   
   Hello Sandy Allen
   The world's tallest woman
   We made friends in New York
   Don't know if you'll remember
   I'm bound to say I felt uneasy
   when I first laid eyes on you
   But I liked the way you talked
   Like a living hoper
   Towering over our heads in more ways than one
   The hand that shook my hand was awesome
   It still amazes me
   
   Hope you're happy - Sandy Allen
   Hope your garden is blooming
   We're all staring at the mirror
   tryin' to put our faces on
   Appearance never held you back
   Must be when you're number one
   you don't have to try so hard
   
   Hello Sandy Allen, hello Sandy Allen, hello...
   
   Hope you're happy Sandy Allen
   Hope your garden is blooming
   We're all staring at the mirror
   tryin' to put our faces on
   Appearance never held you back
   Must be when you're number one
   you don't have to try so hard

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2. 2. spiritual droplet 09:25 AM 8/15/08

   Gigantism is usually caused by foreign matter growing in one's pituitary. But like yao ming and some other big guy,they seem to have no abnormal matter in their body, why they are also gigantic?

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3. 3. adrianna lynn ybarra 12:29 PM 1/15/10

   ohh sorry well that does not run in the famliy :(

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