Despite two decades of work, researchers have not been able to create a satisfactory vaccine against Hiv.
Image: HANK MORGAN SPL/Photo Researchers, Inc.
Ten years ago President Bill Clinton set a national goal to develop an AIDS vaccine within a decade. At that time, the human immunodeficiency virus (HIV) that causes AIDS had infected some 25 million people worldwide. Clinton established a research center at the National Institutes of Health and pledged to enlist other nations in the effort.
“There are no guarantees,” he said in a speech delivered at Morgan State University announcing the initiative. “It will take energy and focus and demand great effort from our greatest minds. But with the strides of recent years, it is no longer a question of whether we can develop an AIDS vaccine, it is simply a question of when.”
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Add CommentI think the article is a good summarization. Since some African prostitutes developed immunity, probably a vaccine is possible, perhaps by repeated exposures to many different virus strains.
Reply | Report Abuse | Link to thisI think developers have made this way too complex.
I think removing serum from an infected person, inactivating the virus, through chemical or physical means, and then reintroducing, perhaps repeatedly, the inactivated whole virus in the infected patient might stimulate immunity. It would mean essentially developing a vaccine for each individual with the disease or stimulating their immunity individually but might be possible.
It would not be a preventive strategy to prevent infection but a method of boosting immunity to the infected person's HIV virus.
It might be a method of stimulating immunity similar to that which has developed in the African prostitutes who have developed natural immunity, evidently through repeated exposure to many different strains of HIV virus.
HIV is transmitted by the viral synapse in vivo. Free virus transmission is not the major way HIV is transmitted. This mechanism has been known about for a decade by bench technicians, but only recently is major work being done on it. So no vaccine can ever work because HIV is not transmitted as free virus much.
Reply | Report Abuse | Link to thisThe reason challenge studies in monkeys with SHIV work somewhat for vaccination while human trials don't is simple. The monkeys are challenged with virus rather than bodily fluids teeming with infected leukocytes.
The viral synapse forms between cells, and they transfer sections of membrane material in lipid rafts from cell to cell complete with virus. Vaccine activation [u]increases[/u] transmission by the viral synapse! (A few, like Tilahun Yilma, have said activation imcreases transmission for many years.)
See: http://scholar.google.com/scholar?q=HIV+viral+synapse&hl=en&lr=
Those rarities who control the virus are either mutants in some cellular mechanism, have an unusual endocrine system, or simply lucky. HIV mutates rapidly, but since it is a random process that is interacting with another random process (the immune system of antibody and T cell activation), it won't always do the same thing. In any random process, there is a distribution, and of course some will be outliers on both ends of the curve. There are so many millions of people with HIV, of course there will be these rare fiew, just like we have winners in the Lotto.
Then again, the field has studiously ignored Ewald's work on evolution of virulence that indicates that rapidly progressing HIV primarily exists because of human behavior evolving the disease to a rapid course by huge numbers of contacts. (i.e. extreme promiscuity in the West in the 1970's and 1980's.) I think he's right, but this is politically incorrect to say. Think of that bell curve again. In any population of infected people, rare viruses will have mutated that are either very slow to cause AIDS or cause it very rapidly. Think of it as like a crop planted in a field. Some plants will grow a big crop fast, others will grow slowly. If, for many generations, you pick the fastest growing plants for your next year's crop, what will you produce by selective breeding? Just so, if this virus is in a population of people that are having promiscuous contacts every 15 years, if the virus progresses to AIDS in less that time, that virus will die out. But if you have promiscuous contacts at the rate of hundreds per year, perhaps thousands, then you will favor the faster progressing virus.
So, look around Africa and what do you find? It is the nations that are stable, mostly Muslim, who have strong moral restrictions and even vigilantism against prostitution and promiscuity that have the lowest rates. (No, these are not artifactual either. They really are an orderof magnitude lower.) Sadly, science is not able to tell anyone that restriction on promiscuity and prostitution is what people must do to save their lives and societies from ruin because of political correctness from AIDS activists in the rich nations restricting messages.
Prevention and palliative care are the only way and should get the primary money. Straight talk. We are wasting out resources on HIV. [u]Many[/u] other diseases deserve research money. In the USA for instance, 36,000 people a year die from influenza, and 18,000 from AIDS. Malaria kills 700,000 to 2.7 million per year worldwide. TB causes 2.5 million deaths per year worldwide. There are quite a few other killer diseases that have no vaccine and can't get any money to try for one.
Scientific Experts actually do encourage people to restrict promiscuity (as well as use protection). Science itself is an inanimate tool that neither encourages nor discourages anything (at least no more than a hammer would).
Reply | Report Abuse | Link to thisMay I reiterate a point I mentioned to a doctor: if you cause an infection in a human body ,you cause a specific immune reaction. Therefore,it seems to me that causing a specific infection to attack the aids virus is plausible. The question here is :what agent can be used to cause a specific infection that stimulates the immune system to target the aids virus. Seems to me it is a matter of testing by elimination,trial and error and eventually you will find the correct agent. rmartinosr@verizon.net
Reply | Report Abuse | Link to thisSearch the net as I have for several years, I still have not found the published paper that verifies this statement of yours: In the early 1980s, after identifying the HIV virus as the cause of AIDS. Or doesn't proof matter any more?
Reply | Report Abuse | Link to thisAmiable readers, to maintain the fidelity we published the article in the original language. Las vacunas son una preparación de antígenos que se inyectan en el cuerpo y generan una respuesta de ataque por medio de los anticuerpos que contribuyen a ponerle fin a algún virus o bacteria. Una vez que han sido suministradas en el organismo generan lo que se conoce por memoria inmunológica por lo que, en la mayoría de los casos, vuelven inmune a la persona a esa enfermedad determinada.La inoculación cuenta con antecedentes en China y Turquía, pero la primera vacuna como tal fue inventada, en 1796, por un médico rural inglés llamado Edward Jenner que dio con una forma para combatir la epidemia de la viruela. Jenner, observó que las mujeres que trabajaban ordeñando las vacas contraían una enfermedad que era conocida como la viruela de las vacas, sin embargo, ésta las hacía inmunes a la viruela humana. Así, sacó una muestra de leche de vaca de la mano de una de las granjeras y la inyectó en el brazo de un niño. Éste sufrió los síntomas de la viruela vacuna. Cuarenta y ocho días después, cuando ya no quedaban rastros de la enfermedad, le inyectó una muestra de la viruela humana y éste no padeció ningún síntoma del mal. Basados en esta observación, nosotros planteamos la siguiente hipótesis: las cucarachas son los insectos sobrevivientes más antiguos sobre la faz de la tierra, por su carga atómica que poseen han podido sobrevivir a grandes cataclismos y fenómenos atmosféricos, así también, las terribles bombas atómicas creadas por el hombre. Existes miles de variedades de cucarachas, pero específicamente las cucarachas que viven en las alcantarillas y se alimentan de los residuos vaginales, el semen, las heces fecales y los excrementos. Estas han logrado sobrevivir, son inmunes y son portadoras del virus del sida. De igual manera como Edgard Jenner, hizo su investigación se hará es mismo procedimiento. Queremos decir hay que aumentar la capacidad inmune del cuerpo humano, aumentar los anticuerpos para poder resistir y convivir con el VIH/Sida. Cuando el cuerpo recibe esta dosis de virus o bacterias, el sistema inmunológico se pone en alerta y destruye a estos agentes que le son extraños al organismo. Así, cuando una dosis realmente dañina decide atacar, el cuerpo ya se encuentra preparado para reconocerla y atacarla rápidamente. Edward Jenner nació el 17 de mayo de 1749 en Berkeley, condado de Gloucester, Inglaterra y falleció un 26 de enero de 1823 en la propia localidad de Berkeley. Fue un afamado investigador, médico y poeta.
Reply | Report Abuse | Link to thisAmiable Readers, the proteins of the cockroach are the solution for the vaccine of AIDS.
Reply | Report Abuse | Link to thisThe director of the NIAID, Dr. Anthony Fausi, must initiate the investigation.
What about the proteins in deadly diseases, such as the Ebola virus? Could this be used to, probably treat HIV?
Reply | Report Abuse | Link to thisDear Friend, many thanks to make to contac. The cockroaches are the insects than old in the planet, they are fed on everything and they do not die. Those that lives in the culverts feed on semen and vaginal residues that contain the virus. This protein must be used to create the vaccine. The scientists must initiate the investigation.
Reply | Report Abuse | Link to thisTHERE ALREADY IS AN AIDS VACCINE, DEVELOPED BY DR SAM CHACHOUA, THAT WAS DECLARED 99% EFFECTIVE WITH NO SIDE EFFECTS. CEDARS SINAI PUT THAT IN WRITING, AND SENT THOSE RESULTS, TO DR CHACHOUA.
Reply | Report Abuse | Link to thisTHEN--WHOOPS---CEDAR SINAI SAID, "WE DONT KNOW ABOUT ANY VACCINE----AND WHO IS SAM CHACHOUA???"
IN A COURT CASE, STARTED BY DR CHACHOUA, AGAINST
CEDARS SINAI, THE JUDGED RULED IN FAVOR OF THE GOOD DOCTOR. GOSH, I WONDER WHO WAS RESPONSIBLE FOR THAT? LIKE ANY MURDER INVESTIGATION---JUST FOLLOW THE MONEY. AND YOU'LL FIND YOUR CULPRIT. TOO BAD FOR HUMANITY.
MASS MURDER CAN RUIN YOUR WHOLE DAY.
What is a vaccine
Reply | Report Abuse | Link to thisVaccines are a preparation of antigens which, when injected in the body, generate a reaction of attack through the antibodies which help to put an end to any virus or bacteria. Once they are injected in the body, they generate something which is already known in immunological memory and in most cases, the person becomes immune to this specific disease. Inoculation has been used in China and Turkey, however the first vaccine as such was invented in 1796 by an English rural doctor called Edward Jenner who arrived at a way of fighting against the smallpox epidemy.
Jenner noted that the women who worked at milking the cows contracted a disease known as the cows smallpox, however this made them immune to human smallpox. Thus, he took a sample of cow's milk from the hand of one of the milkmaids and injected it into the arm of a child. The latter developed the symptoms of cow's small pox. Forty-eight days later, when all traces of the disease had disappeared, he injected in the child a sample of human smallpox and the latter did not suffer from any symptoms of the disease. Edward Jenner was born on May 17th, 1749 in Berkeley, county of Gloucester in England. He died on January 26th, 1823 in Berkeley. He was a famous researcher, a rural doctor and a poet, whose discovery of the antismallpox vaccine was definitely vital in the fight against smallpox, a disease which had become an epidemy in various continents. He was also called the sabio-poeta owing to his passion for writing and expressing his feelings through this facet of literature. He had also a great love for music and nature.
On the basis of this observation, we would like to put the following : "THE PROTEIN OF THE COCKROACHES " THE SOLUTION OF THE VACCINE.
The Cockroaches are insects which are the most ancient survivors on the face of the earth. Because of their atomic charge, they have been able to survive the most devastating disasters and atmospheric phenomenons as well as to the terrible atomic bombs created by Man. There is a wide variety of cockroaches, however those which live in sewers and which feed on vaginal residues, semen, faeces and excrements are those which have managed to survive, they are immune and carry the HIV virus. In the same way that Edward Jenner made his enquiry, the same procedure will be followed. We would like to state that the immune capacity of the human body must be increased, as well as the antibodies in order to resist and live with HIV/Aids. When the body receives this dose of virus or bacteria, the immunological system goes on alert and destroys those agents which are external to the body. In this way, when a really harmful dose decides to attack, the body is prepared to recognize it and to quickly attack it.
Please if you have any questions send to me an e-mail.
Best regard and greetings from the Dominican Republic.
Your Sincerely
Mariojos� Angeles
Artist Mariojos� Calle Madame Curie Cond. Vizcaya, Edif. C-4-1, La Esperilla, Santo Domingo, Dominican Republic
"THE PROTEIN OF THE COCKROACHES " THE SOLUTION OF THE VACCINE"
Reply | Report Abuse | Link to thisWhat is a vaccine
Vaccines are a preparation of antigens which, when injected in the body, generate a reaction of attack through the antibodies which help to put an end to any virus or bacteria. Once they are injected in the body, they generate something which is already known in immunological memory and in most cases, the person becomes immune to this specific disease. Inoculation has been used in China and Turkey, however the first vaccine as such was invented in 1796 by an English rural doctor called Edward Jenner who arrived at a way of fighting against the smallpox epidemy.
Jenner noted that the women who worked at milking the cows contracted a disease known as the cows smallpox, however this made them immune to human smallpox. Thus, he took a sample of cow's milk from the hand of one of the milkmaids and injected it into the arm of a child. The latter developed the symptoms of cow's small pox. Forty-eight days later, when all traces of the disease had disappeared, he injected in the child a sample of human smallpox and the latter did not suffer from any symptoms of the disease. Edward Jenner was born on May 17th, 1749 in Berkeley, county of Gloucester in England. He died on January 26th, 1823 in Berkeley. He was a famous researcher, a rural doctor and a poet, whose discovery of the antismallpox vaccine was definitely vital in the fight against smallpox, a disease which had become an epidemy in various continents. He was also called the sabio-poeta owing to his passion for writing and expressing his feelings through this facet of literature. He had also a great love for music and nature.
On the basis of this observation, we would like to put the following : "THE PROTEIN OF THE COCKROACHES " THE SOLUTION OF THE VACCINE.
The Cockroaches are insects which are the most ancient survivors on the face of the earth. Because of their atomic charge, they have been able to survive the most devastating disasters and atmospheric phenomenons as well as to the terrible atomic bombs created by Man. There is a wide variety of cockroaches, however those which live in sewers and which feed on vaginal residues, semen, faeces and excrements are those which have managed to survive, they are immune and carry the HIV virus. In the same way that Edward Jenner made his enquiry, the same procedure will be followed. We would like to state that the immune capacity of the human body must be increased, as well as the antibodies in order to resist and live with HIV/Aids. When the body receives this dose of virus or bacteria, the immunological system goes on alert and destroys those agents which are external to the body. In this way, when a really harmful dose decides to attack, the body is prepared to recognize it and to quickly attack it.
Please if you have any questions send to me an e-mail.
Best regard and greetings from the Dominican Republic.
Your Sincerely
Mariojosé Angeles
Artist Mariojosé Calle Madame Curie Cond. Vizcaya, Edif. C-4-1, La Esperilla, Santo Domingo, Dominican Republic
In 2008, HIV discoverer and Nobel Laureate Luc Montagnier MD admitted that HIV can be CURED WITHIN WEEKS WITHOUT DRUGS, but that the pharmaceutical industry (and their advertisers) push drugs and vaccines because DRUG COMPANIES cannot profit from selling clean water and good nutrition.
Reply | Report Abuse | Link to thishttp://www.omsj.org/multimedia/nobel-laureate-exposes-scam
In 2008, HIV discoverer and Nobel Laureate Luc Montagnier MD admitted that HIV can be CURED WITHIN WEEKS WITHOUT DRUGS, but that the pharmaceutical industry (and their advertisers) push drugs and vaccines because DRUG COMPANIES cannot profit from selling clean water and good nutrition.
Reply | Report Abuse | Link to thisBut don't believe me - watch the video:
http://www.omsj.org/multimedia/nobel-laureate-exposes-scam