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See Inside February 2008

Disease for Darwinism

More kids, less cancer: Huntington's may confer survival benefits

Over the past 35 years, scientists have made several curious discoveries about Huntington’s disease. First, individuals with the neurological disorder are less likely than others to suffer from cancer; second, they tend to have more children than average—about 1.24 children for every one child born to unaffected siblings. Although no one yet knows what is behind these seemingly unconnected findings, a group at Tufts University has proposed that they are linked—and that one of the proteins implicated in Huntington’s may, ironically, provide patients with subtle health benefits.

Huntington’s destroys neurons in the neostriatum, a region of the brain associated with motor control and cognition. As a result, patients have difficulty controlling their movements and experience a range of cognitive and emotional problems. The disease is caused by a mutation that substantially lengthens a gene known as huntingtin, increasing the number of repeated sequences it contains. The length of the gene varies within the general population and becomes problematic only when it exceeds a certain extent. The gene’s length also affects the severity of symptoms.

Although scientists do not know exactly why the mutation causes neurons to die, studies suggest that a protein called p53 plays a role. The protein has many diverse functions: it helps to regulate when cells divide and die and when new blood vessels form. In Huntington’s, levels of p53 in the blood are higher than normal; p53 has also been shown to bind to the protein created from the mutant huntingtin gene. In addition, animals with the mutation seem to develop the disease only if their bodies can make p53. “The link between p53 and Huntington’s disease is very important,” says Akira Sawa, director of the Program in Molecular Psychiatry at Johns Hopkins University.

Given the diversity of p53’s functions, Philip Starks, a biologist at Tufts, and two of his students, Ben Eskenazi and Noah Wilson-Rich, recently speculated that increased p53 could be responsible for the disease’s link to reduced cancer incidence and increased family size. “When Ben located published information on elevated p53 and relatively low cancer levels in Huntington’s disease–positive individuals, it was a minor eureka moment for us,” Starks explains. Because p53 regulates cell division, the protein helps to ward off cancer, so it is not ridiculous to think that higher levels might lower cancer risk, Starks says.

P53 also appears to play a part in immunity, leading Starks and his students to wonder whether Huntington’s patients might also have heightened immune function during their childbearing years—a characteristic that could explain their increased family size. “We expect that the immune system should be positively related with reproductive success,” explains Kenneth Fedorka, an evolutionary biologist at the University of Central Florida. Fedorka emphasizes, however, that the relation between immunity and reproductive success is complex; more research would be needed to tease out whether p53-triggered immune changes would actually lead patients to have more children. In any case, that Huntington’s patients have more kids may explain why some studies suggest that the prevalence of the disease is slowly increasing. (Others maintain that doctors are simply making better diagnoses.)

Starks and his students believe that Huntington’s is an example of antagonistic pleiotropy—a situation in which a gene has opposing effects on an organism. “The same pathological protein aggregates that debilitate Huntington’s sufferers later in life may actually make them stronger and [more] reproductively successful in their prime,” Eskenazi says. Such a mutation can survive, generation after generation, assuming that the deleterious effects do not appear until after childbearing years.

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