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Researchers have traced resilience, the capacity to recover from adversity, to a network of brain regions and chemicals. Beginning early in life, an individual's genes and the interaction of those genes with the environment shape brain circuits that underlie the psychological strengths and behaviors of resilient people.

Critical to building resilience is the capacity to face fears, experience positive emotions, search for adaptive ways to reframe stressful events and benefit from relationships. Thus, resilience relies on neural circuits governing fear, reward, and social and emotional regulation. These circuits overlap at certain brain structures. For example, the amygdala not only regulates fear but also has a major role in reward, through the processing of positive emotions. The nucleus accumbens, the hub of reward, also influences social behaviors such as sociability and pair bonding. The medial prefrontal cortex has a role in all three circuits, helping to regulate social interactions and emotions and relaying that information to other regions to inform higher-level decisions. As a result of the overlap and connections among these circuits, how a person faces fear is correlated with his or her ability to remain upbeat under stress and generate rewarding social experiences in tough times.

The neural circuits of fear, reward and social behaviors are powered by a variety of neurochemicals and hormones. One of these, neuropeptide Y, is a short protein found in the amygdala and other regions that mediate anxiety and fear. Among people under severe stress, such as someone undergoing challenging military training, higher neuropeptide Y levels are connected to better performance. High levels of the stress hormone cortisol, however, are associated with depression. Norepinephrine, another stress hormone, helps us react appropriately to danger by readying us to fight or flee the scene. Unrestrained repeated increases in norepinephrine may create chronic anxiety, however. Dopamine and serotonin, meanwhile, help us stay positive under difficult conditions.

Resilience may also be related to activation of the left prefrontal cortex. When active, this region at the surface of the brain just behind the forehead sends inhibitory signals to the amygdala, quieting anxiety and fear-based emotions and leaving the frontal brain region free to plan and set goals. In this way, a person is better able to persevere, maintain a positive self-image, remain hopeful in stressful times, and plan and act without being overwhelmed by fear or other emotions. Understanding the biological underpinnings of resilience could help researchers and clinicians design psychological and pharmacological interventions that make people better able to overcome adversity. —S.M.S. and D.S.C.

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