Eyes Open, Brain Shut

New brain-imaging techniques are giving researchers a better understanding of patients in the vegetative state

Join Our Community of Science Lovers!


On supporting science journalism

If you're enjoying this article, consider supporting our award-winning journalism by subscribing. By purchasing a subscription you are helping to ensure the future of impactful stories about the discoveries and ideas shaping our world today.


Recent progress in medical care has greatly increased the number of people who survive acute brain damage. Doctors can save the lives of many patients who suffer trauma to the brain (often after a road accident) or a lack of oxygen (for example, after a cardiac arrest or drowning), but if the damage is severe, the victim will slip into a coma. Individuals in this condition do not open their eyes; at best, they will show some reflex movements of the limbs. Coma rarely lasts longer than two to five weeks. Those who regain consciousness typically do so within days. Others will die, and still others will awaken from their coma but remain unconscious, entering what is called the vegetative state.

Even for experts, the vegetative state is a very disturbing condition. It illustrates how the two main components of consciousness can become completely dissociated: wakefulness remains intact, but awareness--encompassing all thoughts and feelings--is abolished. By wakefulness, I mean that patients in a vegetative state have sleep/wake cycles. At the times when they seem to be awake, their eyes open and sometimes wander. At other times they keep their eyes shut and appear to be asleep, although they may open them and stir when touched or spoken to. These patients usually can breathe without technical assistance and can make a variety of spontaneous movements--such as grinding teeth, swallowing, crying, smiling, grasping another's hand, grunting or groaning--but these motions are always reflexive and not the result of purposeful behavior. Typically patients will not fix their eyes on anything for a sustained period, but in rare instances they may briefly follow a moving object or turn fleetingly toward a loud sound.

Steven Laureys is a professor of neurology at the University of Liège and leads the Coma Science Group at Liège University Hospital Center. He has received numerous awards, among them the 2017 Francqui Prize, the most important Belgian science award.

More by Steven Laureys
Scientific American Magazine Vol 296 Issue 5This article was published with the title “Eyes Open, Brain Shut” in Scientific American Magazine Vol. 296 No. 5 ()
doi:10.1038/scientificamerican052007-1JX4FEr3Nkf9DojXlDnYIo

It’s Time to Stand Up for Science

If you enjoyed this article, I’d like to ask for your support. Scientific American has served as an advocate for science and industry for 180 years, and right now may be the most critical moment in that two-century history.

I’ve been a Scientific American subscriber since I was 12 years old, and it helped shape the way I look at the world. SciAm always educates and delights me, and inspires a sense of awe for our vast, beautiful universe. I hope it does that for you, too.

If you subscribe to Scientific American, you help ensure that our coverage is centered on meaningful research and discovery; that we have the resources to report on the decisions that threaten labs across the U.S.; and that we support both budding and working scientists at a time when the value of science itself too often goes unrecognized.

In return, you get essential news, captivating podcasts, brilliant infographics, can't-miss newsletters, must-watch videos, challenging games, and the science world's best writing and reporting. You can even gift someone a subscription.

There has never been a more important time for us to stand up and show why science matters. I hope you’ll support us in that mission.

Thank you,

David M. Ewalt, Editor in Chief, Scientific American

Subscribe