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Fatal Flaw

ARROW INDICATES where two proteins have linked, foiling the folding process and creating a joint protein incapable of action. This occurs when duplicate sequences of amino acids coincide so that they bind between two proteins, rather than the appropriate sequence on the folding protein itself. A random arrangement of hydrophobic and hydrophilic molecules normally prevents this from happening.

Protein aggregation

Images: SANDIA NATIONAL LABORATORIES

Back to To Fold or Not to Fold

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