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See Inside May 2010

Portrait in DNA: Can forensic analysis yield police-style sketches of suspects?

How your genes could reveal what you look like
DNA sequences



PETER/Dazeley Getty Images

Male, short and stout, with dark skin, brown eyes, ­shovel-shaped teeth, type A+ blood and coarse, dark brown hair giving way to pattern baldness. He would have a high tolerance for alcohol and a higher-than-average risk of nicotine dependence—fortunately, he lived thousands of years before humans discovered smoking. The description of a Stone Age Greenland resident published in February paints an extraordinary portrait of a man who vanished more than 4,000 years ago, drawn almost solely from his DNA remains.

The analysis, led by Danish scientists, not only marks the first full sequencing of an ancient human genome but also offers a startling example of how much modern-day detectives can discern just from a suspect’s genetic code. Far beyond using DNA “fingerprints” to link an individual to a crime scene, forensic profiling is edging toward the capability to create a police-artist-style sketch of an unknown person by reading traits inscribed in the genome. “The body interprets the DNA to determine the appearance of the face,” says anthropologist Mark Shriver of Morehouse College, who hopes to duplicate that ability within a decade.

The scientists reconstructing the ancient Greenlander had only a few tufts of hair, preserved in permafrost, from which they extracted DNA. The hair itself is dark and thick and contains chemical traces indicating mainly a seafood diet. From the man’s genes, the researchers resolved a long-standing debate about the origins of Greenland’s paleo-Eskimos by showing he had a pattern of DNA variations most common in Siberian population groups. Having established his ancestral origins in northern Asia, the team could then interpret variations called single-nucleotide polymorphisms (SNPs) in four genes linked to brown eye color in modern Asians. The same method revealed SNPs associated with shovel-shaped front teeth and a dry type of earwax, both traits common in modern Asians and Native Americans. Four more SNPs suggest that he probably had dark skin. Another set of variations typical of populations adapted to cold climates indicates he had a compact body and ample body fat.

Together those traits might not make the ancient Greenlander stand out in a lineup, but they could dramatically narrow the search for suspects. A handful of high-profile criminal cases has already demonstrated the utility of even basic prospective information. In 2007 Christopher Phillips and his colleagues at the University of Santiago de Compostela in Spain used markers in a DNA sample obtained from a toothbrush to identify a suspect in the 2004 Madrid train bombing as being of North African descent. Police later confirmed that the terrorist was Algerian. In an infamous Louisiana serial killer investigation, witness testimony had indicated a Caucasian culprit, but DNA evidence pointed to someone of significant African-American and Native American descent. Police widened their search and eventually caught the killer.

Having more to go on than ancestry, a generally poor indicator of appearance, is the goal of programs such as the DNA Initiative of the National Institute of Justice, which funds research into alternative genetic markers for forensic use. Daniele Podini of George Washington University is developing a forensic kit to determine, by analyzing 50 to 100 genetic markers, a suspect’s eye and hair color, sex and probable ancestry. “The idea is just to provide another investigational tool,” he says, “one that can help corroborate the testimony of a witness or reduce the number of suspects.”

Getting more specific gets significantly more difficult, Podini adds. DNA alone offers few clues to age, for instance. With whole cells, researchers could examine telomeres, the chromosomal end caps that wear away with time, but individual health and other factors can influence their shrinkage. One recent study showed that dedicated athletes in their 50s might have the telomeres of a 25-year-old. Another important feature in profiling, height, has hereditary roots but also depends on environmental factors, such as nutrition during childhood.

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