See Inside August/September 2006

Prozac Spurs Neuron Growth ...

Recent work with mice has revealed that the antidepressant Prozac spurs growth of new neurons in the brain. Prozac, or fluoxetine, is thought to ease depression by raising the level of the neurotransmitter serotonin in the brain. But now researchers have learned that the drug also causes more neurons to form than normally would. In mice, blocking this growth nullifies the drug's effects on behavior, suggesting that neuron formation may be part of the mechanism that alleviates depression.

How exactly fluoxetine boosts neuron formation, called neurogenesis, is unclear. Neurogenesis consists of several rounds of cell division that create many neurons from a few stem cells. To pinpoint fluoxetine's effect on this pathway, a group at Cold Spring Harbor Laboratory on Long Island, N.Y., created a strain of mouse with neural stem cells that contained a green fluorescent protein in their nuclei, making the cells easy to track under a microscope. They found that fluoxetine works on the second stage of neurogenesis, causing cells called amplifying neural progenitors to reproduce at a 50 percent greater rate than usual. This step is therefore “a clear target for the action of an antidepressant,” which may help in designing better antidotes, says study leader Grigori Enikolopov.

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