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The Long Arm of the Immune System [Preview]

Dendritic cells catch invaders and tell the immune system when and how to respond. Vaccines depend on them, and scientists are even employing the cells to stir up immunity against cancer

They lie buried—their long, tentaclelike arms out stretched—in all the tissues of our bodies that interact with the environment. In the lining of our nose and lungs, lest we inhale the influenza virus in a crowded subway car. In our gastrointestinal tract, to alert our immune system if we swallow a dose of salmonella bacteria. And most important, in our skin, where they lie in wait as stealthy sentinels should microbes breach the leathery fortress of our epidermis.

They are dendritic cells, a class of white blood cells that encompasses some of the least understood but most fascinating actors in the immune system. Over the past decade, researchers have begun to unravel the mysteries of how dendritic cells educate the immune system about what belongs in the body and what is foreign and potentially dangerous. Intriguingly, they have found that dendritic cells initiate and control the overall immune response. For instance, the cells are crucial for establishing immunological “memory,” which is the basis of all vaccines. Indeed, physicians, including those at a number of biotechnology companies, are taking advantage of the role that dendritic cells play in immunization by “vaccinating” cancer patients with dendritic cells loaded with bits of their own tumors to activate their immune system against their cancer. Dendritic cells are also responsible for the phenomenon of immune tolerance, the process through which the immune system learns not to attack other components of the body.

But dendritic cells can have a dark side. The human immunodeficiency virus (HIV) hitches a ride inside dendritic cells to travel to lymph nodes, where it infects and wipes out helper T cells, causing AIDS. And those cells that become active at the wrong time might give rise to autoimmune disorders such as lupus. In these cases, shutting down the activity of dendritic cells could lead to new therapies.

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