The Risks on the Table [Preview]

More than half the foods in U.S. supermarkets contain genetically modified ingredients. Have they been proved safe for human consumption?

A farmworker crouches in the hot Texas sun, harvesting celery for market. That evening, painful red blisters erupt across his forearms. The celery--a newly developed variety prized for its resistance to disease--unexpectedly produces a chemical able to trigger severe skin reactions.

Traditional breeding methods generated this noxious vegetable. But opponents of genetically modified foods worry that splicing foreign genes (often from bacteria) into food plants through recombinant-DNA technology could lead to even nastier health surprises. The stakes are high: GM foods are sold in many countries. In the U.S., an estimated 60 percent of processed foods in supermarkets--from breakfast cereals to soft drinks--contain a GM ingredient, especially soy, corn or canola.

Detractors cite several reasons for concern. Perhaps proteins made from the foreign genes will be directly toxic to humans. Maybe the genes will alter the functioning of a plant in ways that make its food component less nutritious or more prone to carrying elevated levels of the natural poisons that many plants contain in small amounts. Or perhaps the modified plant will synthesize proteins able to elicit allergic reactions.

Allergy was the big worry in 2000 when StarLink corn--genetically modified to produce an insecticidal protein from the bacterium Bacillus thuringiensis (Bt)--turned up in taco shells, corn chips and other foods. StarLink had been planted after receiving approval for use in animal feed, but concerns about the potential allergenicity of its particular version of the Bt protein kept the corn from gaining approval for human consumption. Although U.S. regulators found no cases of allergic reaction that could be attributed to the consumption of food containing small amounts of StarLink corn, the product was removed from the market.

Proponents offer a number of defenses for genetically engineered foods. Inserting carefully selected genes into a plant is safer than introducing thousands of genes at once, as commonly occurs when plants are crossbred in the standard way. GM crops designed to limit the need for toxic pesticides can potentially benefit health indirectly, by reducing human exposure to those chemicals. More directly, foods under study are being designed to be more nutritious than their standard counterparts. Further, GM crops that produce extra nutrients or that grow well in poor conditions could provide critical help to people in developing nations who suffer from malnutrition.

Advocates note, too, that every genetically engineered food crop has been thoroughly tested for possible health effects. Relatively few independent studies have been published, but manufacturers have conducted extensive analyses, because they are legally required to ensure that the foods they sell meet federal safety standards. Companies voluntarily submit these test results to the U.S. Food and Drug Administration in advance of sale.

The manufacturers studies typically begin by comparing the GM version under consideration with conventionally bred plants of the same variety, to see whether the addition of a foreign gene significantly alters the GM plant's chemical makeup and nutritional value. If the proteins made from the inserted genes are the only discernible differences, those proteins are checked for toxicity by feeding them to animals in quantities thousands of times higher than humans would ever consume. If the genetic modification leads to more extensive changes, toxicity testers may feed the complete GM food to laboratory animals.

To assess the allergy-inducing potential, scientists check the chemical makeup of each novel protein produced by the genetically altered plant against those of 500 or so known allergens; having a similar chemistry would raise a red flag. Proteins are also treated with acid to mimic the environment they will encounter in the stomach; most known allergens are quite stable and survive such treatment unscathed. Finally, investigators consider the original source of the protein. "There is no way that a peanut gene will ever be allowed into a strawberry," observes Thomas J. Higgins of the Commonwealth Scientific and Industrial Research Organization in Australia: too many people are allergic to proteins in peanuts.

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