ADVERTISEMENT

The Shape of Alzheimer's

THIS IS A PREVIEW.
or subscribe to access the full article.

Researchers are a step closer to understanding how Alzheimer's disease takes shape—literally.

A hallmark of Alzheimer's is the presence of protein aggregates in the brain known as plaques. They are made up of various lengths and conformations of the beta amyloid protein. The proteins link end to end, forming long, threadlike structures called fibrils. Now Roland Riek and his colleagues at the Salk Institute for Biological Studies in San Diego, working with scientists at the University of Lausanne in Switzerland and the F. Hoffmann–La Roche company, have constructed a three-dimensional model of the fibrils based on their own experiments and earlier data published by others.

THIS IS A PREVIEW.
or subscribe to access the full article.
Buy Digital Issue $7.95
Digital Subscription $19.99 Subscribe
Share this Article:

Comments

You must sign in or register as a ScientificAmerican.com member to submit a comment.
Scientific American Holiday Sale

Scientific American Mind Digital

Get 6 bi-monthly digital issues
+ 1yr of archive access for just $9.99

Hurry this offer ends soon! >

X

Email this Article

X