Given her background and curiosity, Helen Mayberg seems to have been destined from girlhood to do what she is doing now--even though her current work was inconceivable then. Her father practiced family medicine in Los Angeles County. Her uncle used x-rays and nuclear medicine machines to research biochemistry. Today Mayberg peers into brains to examine mood networks--and with one startling experiment has transformed the treatment of depression. At the same time, by combining her father's bedside dedication with her uncle's technical sophistication, she is changing the leading theories of how thought and mood interact.