• Genes that control an organism's ability to withstand adversity cause changes throughout the body that render it temporarily supercharged for survival.
  • Activated over the long term, this stress response prolongs life span and forestalls disease in a wide range of organisms.
  • Sirtuins are a family of genes that may be master regulators of this survival mechanism.
  • Understanding how they produce their health and longevity-enhancing effects could lead to disease treatments and ultimately longer, disease-free human life spans.