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Bioinformatician, Clinical NGS

Employer: Ontario Institute for Cancer Research
Posted: January 15, 2014
Expires: November 5, 2014
Requisition number:

Science jobs from Ontario Institute for Cancer Research:
Position: Bioinformatician, Clinical NGS Site: MaRS Centre, Toronto Department:Informatics & Biocomputing Reports To:Dr. Paul C. Boutros Salary:Flexible based on experience Hours:35 Hrs/week Status: Full-Time, Permanent

Are you a guru in next-generation sequencing? The Ontario Institute for Cancer Research (OICR) is seeking a talented Bioinformatician to focus on the analysis of large clinical next-generation sequencing (NGS) datasets. We want somebody with an extensive interest in large-data problems, and an in-depth knowledge of data-handling. The successful applicant will be working closely with a highly integrated team of systems-administrators, software-engineers, statisticians, PhD students and post doctoral associates on:

Optimization and parallelization of algorithms for the analysis of genome-sequencing data Automating procedures for pipeline evaluation and assessment Creating pipelines with the robustness and provenance-tracking needed for clinical use Downstream data-modeling, including pathway analysis and clinical association studies * Extensive data-visualization

You'll be working with some of the largest NGS datasets in the world, including paired WGS and RNA-Seq in 500 prostate cancers (CPC-GENE), the ICGC pan-cancer initiative (2000 tumour/normal whole-genomes and >8000 exomes) and the on-going DREAM Somatic Mutation Calling Challenge. We have an extensive computational infrastructure, including a >8000-core computing cluster and multi-petabyte storage. This is a unique opportunity to develop your strong computational skillset to create the pipelines needed for clinical-sequencing and to apply them to unique datasets that will help us rewrite the textbook of cancer genomics.

QUALIFICATIONS BSc or equivalent education in computational biology, engineering, mathematics, computer sciences or molecular biology Strong background with unix/linux tools and administration Experience in high performance computing on a large scale cluster using Sun Grid Engine (i.e. SGE) Strong programming skills, preferrably in R/perl, required Exposure to next-generation sequencing data is mandatory Statistical background in machine-learning, survival or Bayesian techniques is an asset Proven experience with bioinformatics resources and/or databases is an asset Experience working with test-driven programming and version control is a major asset

OICR is an innovative new cancer research institute located in the MaRS Centre in the Discovery District in downtown Toronto. OICR is addressing significant challenges in cancer research with multi-disciplinary, multi-institutional teams. New discoveries to prevent, detect and treat cancer will be moved from the bench to practical applications in patients. The OICR team is growing quickly. We are innovative, dedicated professionals who bring expertise to each of our roles. We are looking for individuals interested in being part of a culture of excellence that will result in Ontario being recognized internationally as a leading jurisdiction for cancer research.

Launched in December 2005, OICR is an independent institute funded by the Government of Ontario through the Ministry of Research and Innovation.

For more information about OICR, please visit the website at

POSTED DATE: March 25, 2014 CLOSING DATE: posted until filled

HOW TO APPLY: Interested applicants must apply here:

Don't forget to mention NatureJobs when applying.

Apply for Ontario Institute for Cancer Research
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