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Posted: January 15, 2014
Expires: March 15, 2014
Requisition number: Irtelis PhD project
Science jobs from Commissariat à l'Energie Atomique (CEA):
Description: Damaged DNA generates mutations and genomic instability that ultimately threaten cell or organism viability. Recognition of DNA damage is a very challenging cellular process, which consists in detecting rare modifications to the DNA in a large pool of intact genomic material. The goal of the proposed project is the study of the dynamics of DNA damage localisation, recognition and repair processes in the radiation-resistant bacterium Deinococcus radiodurans. The project will focus on the nucleotide excision repair pathway that is responsible for the removal of a wide variety of structurally unrelated lesions. The objectives are to investigate the cellular localisation and dynamics of these proteins in vivo using "super-resolution" fluorescence microscopy. In this frame, the so-called "PALM" super-resolution microscopy technique, based on the detection of single molecules, will be developed so as to carry out quantitative, multi-colour imaging. We expect this work to shed light on the mechanisms used by repair proteins to locate and repair their DNA substrates and, at the same time to contribute to the development of nanoscale fluorescence imaging.
Profile needed: The candidate should hold a Master degree in Biology, Physics or Biophysics. A background in both Physics and Biology would be a bonus. Experience in fluorescence imaging techniques, cell culture and molecular biology are desirable.
Recruitment process: 1 - January to March 2014: selection of a candidate by the host laboratory. Deadline for application for a CEA PHD grant: 21st March 2014 2 - April & May 2014: Selection of candidates 3 - September 2014: start of the project More info: http://www-dsv.cea.fr/dsv/phd-program/le-concours-irtelis
Information/Application http://www.ibs.fr/groups/viral-infection-and-cancer-group/timmins-team/dynamics-of-dna-damage-repair/?lang=en Contact: firstname.lastname@example.org Please send CV + cover letter + 2 supporting letters
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