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Postdocs: mechanotransduction in development
Posted: January 15, 2014
Expires: March 16, 2014
Science jobs from INRA (French National Institute for Agricultural Research):
We will conduct a multiscale investigation into mechanotransduction, at the level of a cell, of a small group of cells, and of the tissue. We have already characterized the response of microtubules to mechanical stress using a set of micromechanical tools in these three systems, and shown how mechanical stress can add robustness to morphogenetic events via the modulation of growth rate, growth anisotropy and growth heterogeneity (Hamant et al., 2008 Science; Heisler et al., 2010 Plos Biol.; Uyttewaal et al., 2012 Cell). The main goal of this ERC-funded project is to identify and characterize elements of the plant mechanotransduction pathways, including mechanosensitive genes and proteins, based on preliminary results and on a well-designed screen. In parallel, we will develop cutting-edge micromechanical tools and tension sensors to monitor and quantify mechanical stress locally. Scaling up, we will generate transgenic lines in which patches of cells with altered mechanical properties can be induced, and we will test whether mechanical heterogeneities are used to coordinate cell wall remodeling and cell division between adjacent cells. Last, we will investigate whether these biophysical coordinating mechanisms contribute to patterning and cell fate in organs.
Environment The Plant Reproduction and Development Institute (Lyon, France) is among the world leading centers working on plant development. With expertise in molecular biology and imaging, it increasingly develops systems biology to simulate the behavior of gene networks and tissues. Although the project is focused on molecular and cell biology, the postdocs will join an interdisciplinary team composed of physicists, computer scientists and biologists. Lyon is a vibrant city with many cultural and sportive opportunities, 2 hours from the Alps, Paris or the Mediterranean sea.
Starting date is July 2014 and onwards. Team website: http://www.ens-lyon.fr/RDP/spip.php?rubrique19&lang=en Lyon: http://www.onlylyon.org/onlylyon-org-42-2.html
How to apply? We are looking for highly motivated candidates with strong involvement in their research project and with good background and practical skills in molecular and cellular biology (in plants or in other systems). Applications should be sent by email to Olivier.email@example.com with a CV and two reference letters (Feel free to contact me with questions and/or ideas to discuss beforehand too).
Apply for INRA (French National Institute for Agricultural Research)
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