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Ph.D. position in microfluidic development applied to synthetic biology
Posted: January 18, 2014
Expires: March 17, 2014
Science jobs from Université de Rennes 1:
Synthetic biology has emerged as a powerful tool to understand essential biological functions. This approach relies on the implementation and external control of artificial regulatory systems that can recapitulate biological processes. In the last decade, it has led to novel insights into core regulatory mechanisms that are at the basis of cellular life. Furthermore, it brings together scientists of various backgrounds, from biologists to physicists to engineers. The SyntheCell laboratory takes a synthetic approach using fission yeast as a model system to investigate the architecture and evolution of the eukaryotic cell cycle.
Controlling artificial systems in vivo is a challenge, especially when this needs to be coupled with high resolution imaging. In particular, the precise, simultaneous management of several environmental parameters with a high temporal resolution is difficult to achieve. Microfluidic technology provides one of the most promising approaches to overcome such limitations. This interdisciplinary project aims at 1) developing a highly versatile microfluidic platform for fast, precise and simultaneous control of a wide range of environmental parameters while allowing high resolution imaging and 2) using the device to study fission yeast strains operating with minimal synthetic cell cycle control circuits.
We are seeking highly motivated candidates to take on this innovative project at the interface between fundamental biology and engineering. Candidates must hold an engineer diploma and a Master's degree or equivalent and have a background in physics, with notions of biology. Candidates with skills in programming and simulation are encouraged to apply. A good level of spoken and written English is required. Applications including a detailed Curriculum Vitae and motivation letter should be sent by email to Dr. Damien Coudreuse (firstname.lastname@example.org)
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