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Posted: January 20, 2014
Expires: March 19, 2014
Science jobs from UCLA:
This position is open summer or fall of 2014 in the Lo Laboratory, which addresses key challenges in the development of novel melanoma therapeutics. We have focused on how BRAF mutant melanomas adapt to and acquire resistance to BRAF inhibitors (or BRAF plus MEK inhibitors) and how the BRAF inhibitors induce secondary neoplasms. Our current research tackles layers of complexity, during the evolution of resistance, including signaling, epigenetic and metabolic reprogramming underlying melanoma dormancy and phenotypic plasticity. We seek to also understand the functional interface between melanoma and its tumor-infiltrating neighboring cells, including immune-regulatory and immune cells. Finally, we look for therapeutic opportunities from our pre-clinical and clinical tissue correlative studies and promote clinical trial testing of novel therapeutic concepts.
We are affiliated with the Department of Medicine/Division of Dermatology, Department of Molecular and Medical Pharmacology, and the Jonsson Comprehensive Cancer Center (Signal Transduction and Therapeutics Program) at the University of California, Los Angeles.
The ideal candidates must have extensive experience handling RNA, DNA, and protein. His or her skill set should include molecular cloning, immunohistochemistry, immunoprecipitation, FACS analysis, immuno-blotting, mammalian cell culture, viral transduction, microscopy, and small animal work. Strength in bioinformatic skills and knowledge of cancer metabolism or epigenetics are significant pluses. Fluency in English and strong written and oral communication skills are pre-requisites. US permanent residency or citizenship is not required although preferred. Interested individuals should have at least two first-authored publications in a top-ranked peer-reviewed journal. Please forward a CV along with three letters of recommendation, one of which from the doctoral thesis advisor to firstname.lastname@example.org.
Posting date January, 2014.
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