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Principal Research Associate, Protein Analytics


Employer: Adimab, LLC
Location:
Posted: June 12, 2014
Expires: August 8, 2014
Requisition number:

Science jobs from Adimab, LLC:
Adimab is looking for an experienced biochemist with hands-on knowledge of biophysical characterization of proteins or antibodies to join its team. The successful candidate will be responsible for performing in vitro kinetic assays with purified antibodies and antigen using BLI or solution equilibrium titrations. In addition, as a member of our Protein Analytics team, the candidate would be expected to perform stability studies as well as analytical chromatographic and dynamic light scattering techniques to help our Antibody Discovery team identify antibodies as potential therapeutic leads.

At Adimab, we use our proprietary yeast-based antibody discovery and protein engineering platform to provide the biopharmaceutical industry with human therapeutic antibodies of the highest quality. We create long-term value with top-tier pharmaceutical and highly innovative biotechnology companies that share our passion for bringing best-in-class molecules to patients.

Responsibilities

The successful candidate will work in a small team setting to support Adimab's novel antibody discovery, maturation, and production platform by performing the following assays:

Real-time (BLI) and solution equilibrium titration measurements of antibody:antigen affinity Competition assays to determine epitopic coverage of selected antibodies Antibody thermostability assays (DSF) Chromatographic techniques such as analytical size exclusion chromatography using HPLC Mass identification of antibodies and antigen by LC-MS Quality control assays on both antibodies and antigen

Qualifications

B.A./B.S. with 4+ years or M.S. with 2+ years in an academic lab or an industrial biopharmaceutical or biotechnology setting Effective communication skills Adaptable and productive in a fast-paced environment Depth of technical knowledge in kinetics Strong biophysics/biochemistry background as demonstrated by publications or defined coursework with emphasis in these areas Minimum of 2 years hands-on experience with independently designing and implementing kinetic assays (SPR, solution phase affinity measurements, etc.) Strong technical knowledge in SPR or BLI affinity measurements and ELISAs Applied knowledge of data fitting of kinetic data (Prism, KaleidaGraph, Origin, etc.)

Adimab's proprietary yeast-based antibody discovery and optimization platform functions as a synthetic human immune system to create novel antibody therapeutics targeting antigens across an extensive range of diseases, including cancer as well as autoimmune and infectious diseases. We are a profitable privately-held biotech company backed by top-tier venture capital firms including Google Ventures, OrbiMed Advisors, Polaris Partners, and SV Life Sciences. We are unique in our ability to take a long-term view on value creation which allows us to continuously refine and improve our technology and make substantial investments in R&D.

Located in New Hampshire's beautiful Upper Connecticut River Valley, the Adimab labs are minutes from Dartmouth College, the Geisel School of Medicine, the Thayer School of Engineering, the Tuck School of Business, and the Dartmouth Hitchcock Medical Center. We are fortunate to be situated near the Appalachian Trail in an area that is renowned for its premier skiing, hiking, canoeing, and kayaking.

At Adimab, we offer individually-tailored compensation packages comprised of competitive salary, equity, 2:1 401(k) match, and comprehensive health care benefits including a gym membership, in addition to a world class working environment in a newly constructed lab.

Don't forget to mention NatureJobs when applying.

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