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Senior Scientist, Protein Analytics


Employer: Adimab, LLC
Location:
Posted: June 12, 2014
Expires: August 8, 2014
Requisition number:

Science jobs from Adimab, LLC:
Adimab is seeking a senior biochemist with experience in biophysical characterization of proteins or antibodies to join its team. The Senior Scientist will be responsible for performing in vitro kinetic assays with purified antibodies and antigens using Bio-Layer Interferometry (BLI) or solution equilibrium titrations. In addition, the Senior Scientist will perform stability studies and analytical chromatographic and dynamic light scattering (DLS) techniques to help our Antibody Discovery team identify antibodies as potential therapeutic leads.

At Adimab, we use our proprietary yeast-based antibody discovery and protein engineering platform to provide the biopharmaceutical industry with human therapeutic antibodies of the highest quality. We create long-term value with top-tier pharmaceutical and highly innovative biotechnology companies that share our passion for bringing best-in-class molecules to patients.

Responsibilities

Measure both real-time BLI and solution equilibrium affinity of antibodies to their antigen Determine epitopic coverage of selected antibodies using competition assays Carry out antibody thermostability assays using differential scanning fluorimetry (DSF) Use nanoparticles to assess antibody self-association Utilize chromatographic techniques such as analytical size exclusion chromatography using HPLC, hydrophobic interaction chromatography, and cross-interaction chromatography Execute established assays and develop new assays to predict antibody developability Perform mass identification of antibodies and antigens by LC-MS Carry out DLS techniques for antigen and antibody characterization Perform antigen QC to ensure a successful antibody selection campaign using SEC, stability tests, and related biophysical characterizations Characterize the delivery set of antibodies for the customer with techniques including DSF, ForteBio binding, binning, LC-MS, etc.

Qualifications

Ph.D. with a minimum of 5 years in an industrial biopharmaceutical or biotechnology setting Strong biochemistry background with a depth of technical knowledge in kinetics, as demonstrated by publications Minimum of 2 years hands-on experience in independently designing and implementing kinetic assays (SPR, solution phase affinity measurements, etc.) Technical proficiency in SPR or BLI affinity measurements and ELISAs Applied knowledge of data fitting of kinetics (Prism, KaleidaGraph, Origin, etc.) Proven track record of clear and open communication with direct reports, peers, and supervisors Adaptable and productive in a fast-paced environment Supervisory experience preferred

Adimab's proprietary yeast-based antibody discovery and optimization platform functions as a synthetic human immune system to create novel antibody therapeutics targeting antigens across an extensive range of diseases, including cancer as well as autoimmune and infectious diseases. We are a profitable privately-held biotech company backed by top-tier venture capital firms including Google Ventures, OrbiMed Advisors, Polaris Partners, and SV Life Sciences. We are unique in our ability to take a long-term view on value creation which allows us to continuously refine and improve our technology and make substantial investments in R&D.

Located in New Hampshire's beautiful Upper Connecticut River Valley, the Adimab labs are minutes from Dartmouth College, the Geisel School of Medicine, the Thayer School of Engineering, the Tuck School of Business, and the Dartmouth Hitchcock Medical Center. We are fortunate to be situated near the Appalachian Trail in an area that is renowned for its premier skiing, hiking, canoeing, and kayaking.

At Adimab, we offer individually-tailored compensation packages comprised of competitive salary, equity, 2:1 401(k) match, and comprehensive health care benefits including a gym membership, in addition to a world class working environment in a newly constructed lab.

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