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Post-doctoral Position in Development and Stem cells


Employer: Inserm (CDD)
Location:
Posted: July 22, 2014
Expires: September 15, 2014
Requisition number:

Science jobs from Inserm (CDD):
A Post-doctoral position is available in the team directed by Dr Frédéric Relaix at Hopital Pitié-Salpétrière in Paris, France.

This research group is interested in : (1) Pax3 and Pax7 functions during development and stem cells, (2) the modulation of environmental signaling during development, (3) interactions of muscle stem cells with their environment, (4) the identification of novel regulators of development and myogenesis, (5) skeletal muscle biology from fundamental research to muscle disease therapy.

A salary is available, however the candidates are expected to be competitive and to be able to obtain their own independent financing. Selected candidates are expected to start immediately. A PhD with a strong background in molecular biology, and/or mouse molecular genetics, stem cell biology, developmental biology is strongly advised.

Selected candidates should be enthusiastic and highly motivated to work in a dynamic and well-funded scientific environment. Scientific English is required, and foreign candidates (notably EC members) are encouraged to apply.

Applications, including scientific interests, a detailed CV and the name of two referees should be sent to Dr Frédéric Relaix (frelaix@gmail.com).

Selected publications :

Zalc, A., Hayashi, S., Aurade, F., Brohl, D., Chang, T., Mademtzoglou, D., Mourikis, P., Yao, Z., Cao, Y., Birchmeier, C. and Relaix, F. 2014, Antagonistic regulation of p57kip2 by Hes/Hey downstream of Notch signaling and mucle regulatory factors regulates skeletal muscle growth arrest. Development. In press

Lagha, M., Chang, T., Mayeuf, A., Montarras, D., Rocancourt, D., Kormish, J., Zaret , K., Buckingham ; M. and Relaix, F. 2013. Itm2a is a Pax3 target gene, expressed at sites of skeletal muscle formation in vivo. PLoS ONE, 8 :e63143.

Hayashi, S., Rocancourt, D., Buckingham, M. and Relaix, F. 2011. Lack of in vivo functional compensation between Pax family groups II and III in rodents. Mol. Biol. Evol. 28(10):2787-98.

Ho, A.T., Hayashi, S., Bröhl, D., Auradé, F., Rattenbach, R. and Relaix, F. 2011. Neural crest cell lineage restricts skeletal muscle progenitor cell differentiation through Neuregulin1-ErbB3 signaling. Dev Cell. 21 : 273-87.

Lagha, M., Brunelli, S., Messina, G., Cumano, A., Kume, T., Relaix, F. and Buckingham, M.E. 2009 Pax3 :Foxc2 reciprocal repression in the somite modulates luscular versus vascular cell fate choice in multipotent progenitors. Dev Cell. 17(6):892-9.

Relaix, F., Rocancourt, D., Mansouri, A. and Buckingham, M. (2005). A Pax3/Pax7-dependent population of skeletal muscle progenitor cells. Nature, 435, 948-953

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