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Postdoctoral Positions in Cancer immunology

Employer: Cold Spring Harbor Laboratory (CSHL)
Posted: July 30, 2014
Expires: September 26, 2014
Requisition number: 00942-R

Science jobs from Cold Spring Harbor Laboratory (CSHL):
*Postdoctoral Positions in Cancer immunology in the Fearon lab.*

The laboratory of Douglas Fearon is seeking an outstanding postdoc fellow for research on the antigens expressed by mouse and human pancreatic cancer cells using T cell receptors cloned from individual, cancer cell-reactive CD8+ T cells and ribosome profiling techniques. We are particularly interested in candidates with an interest in new approaches to cancer immunology.

The antigens expressed by cancer cells that mediate the immune responses that control cancer growth in humans are not known. Our laboratory has recently discovered that the spontaneous CD8+ T cell response to unknown cancer cell antigens in an autochthonous model of pancreatic ductal adenocarcinoma is capable of rapidly eliminating cancer cells once immune suppression has been relieved (Feig, et al. PNAS 2013). We suspect that the expression by cancer cells of these antigens reflects the metabolic state of these cells and, therefore, represents a "normal" cellular response. Defining the antigens would lead not only to support for this concept, but also to improved therapy of human cancer. The project will involve collaboration with a laboratory at MIT for identifying cancer cell-reactive CD8+ T cells, and the use of ribosome profiling to identify candidate antigens.

Successful candidates are expected to stand out through their ongoing original research in the broad areas of molecular, cell or cancer biology. They should either hold or be within a year from obtaining their Ph.D.

(Further information on the Fearon lab can be found online)

Qualified applicants are invited to apply for this position via the CSHL careers website at:

Position number: 00942-R

Please include a cover letter describing your previous experience, summary of research accomplishments, and interest in this position; your CV and the names and contact information for three references.

For more information about CSHL, please visit us at

CSHL is an EO/AA Employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, national origin, age, disability or protected veteran status.

Don't forget to mention NatureJobs when applying.

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