Millions Risk Alcohol–Medication Interactions

Some 42 percent of U.S. adults who drink have been prescribed a drug that may interact negatively with alcohol. Dina Fine Maron reports

Join Our Community of Science Lovers!


On supporting science journalism

If you're enjoying this article, consider supporting our award-winning journalism by subscribing. By purchasing a subscription you are helping to ensure the future of impactful stories about the discoveries and ideas shaping our world today.


Almost three quarters of American adults drink alcoholic beverages. Sooner or later, many of them will also take a prescribed medication. The fine print that comes with some meds tells patients to forgo booze while taking the drugs—because alcohol-medicine interactions can change a drug’s effectiveness, or cause other health issues.

Researchers have long wondered how much drinking goes on by people on such drugs, despite the warnings.

Now a study suggests that almost 42 percent of U.S. drinkers have at some point been in possession of one or more alcohol-interactive drugs. The data do not guarantee that patients drank while on the drugs. But the research team notes that the numbers highlight the need for physicians to clearly discuss the potential risks of combining alcohol with certain meds, including ones commonly prescribed, for example, for depression, diabetes or high blood pressure.

The findings are in the journal Alcoholism: Clinical and Experimental Research and are based on info from more than 26,000 adults collected by the 1999 to 2010 National Health and Nutrition Examination Survey. [Rosalind A. Breslow, Chuanhui Dong and Aaron White, Prevalence of Alcohol-Interactive Prescription Medication Use Among Current Drinkers: United States, 1999 to 2010]

Elderly patients typically use more prescription drugs than younger people. And the study found that almost 78 percent of elderly drinkers have the potential to be drinking while taking drugs that warn against it.  

We know not to drink and drive. When it comes to some meds, don’t drink and dose.

—Dina Fine Maron

[The above text is a transcript of this podcast.]

It’s Time to Stand Up for Science

If you enjoyed this article, I’d like to ask for your support. Scientific American has served as an advocate for science and industry for 180 years, and right now may be the most critical moment in that two-century history.

I’ve been a Scientific American subscriber since I was 12 years old, and it helped shape the way I look at the world. SciAm always educates and delights me, and inspires a sense of awe for our vast, beautiful universe. I hope it does that for you, too.

If you subscribe to Scientific American, you help ensure that our coverage is centered on meaningful research and discovery; that we have the resources to report on the decisions that threaten labs across the U.S.; and that we support both budding and working scientists at a time when the value of science itself too often goes unrecognized.

In return, you get essential news, captivating podcasts, brilliant infographics, can't-miss newsletters, must-watch videos, challenging games, and the science world's best writing and reporting. You can even gift someone a subscription.

There has never been a more important time for us to stand up and show why science matters. I hope you’ll support us in that mission.

Thank you,

David M. Ewalt, Editor in Chief, Scientific American

Subscribe