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Special Report

Personalized Medicine in the Genomic Era

When the human genome draft was announced 10 years ago, many researchers and policymakers anticipated using the newly sequenced code to develop a wealth of diagnostic and treatment capabilities. But the genetic components of disease have proved more complex

  • June 24, 2010

A genome story: 10th anniversary commentary by Francis Collins

For those of you who like stories with simple plots and tidy endings, I must confess the tale of the Human Genome Project isn't one of those. The story didn't reach its conclusion when we unveiled the first draft of the human genetic blueprint at the White House on June 26, 2000.

June 25, 2010 — Francis Collins

New genetic associations for Alzheimer's disease

The long and winding journey to the roots of Alzheimer's disease, the most common form of dementia, has turned up three new genetic clues—the first major ones in 15 years.

September 8, 2009 — Katherine Harmon

Knowing Your Chances: What Health Stats Really Mean

Learn how to put aside unjustified fears and hopes and how to weigh your real risk of illness—or likelihood of recovery

April 1, 2009 — Gerd Gigerenzer, Wolfgang Gaissmaier, Elke Kurz-Milcke, Lisa M. Schwartz and Steven Woloshin

Meet my genome: 10 people release their DNA on the Web

Ten people today allowed their genetic maps to be publicly displayed on the Web in the name of research. The effort is part of Harvard Medical School's Personal Genome Project (PGP), which aims to create a large public database of human DNA to aid researchers in their quest to find the causes and cures for genetic maladies.   

The first 10 volunteers, dubbed the PGP-10, include project director and Harvard Medical School geneticist George Church; Harvard psychologist Steven Pinker; technology writer Esther Dyson; Duke University science editor Misha Angrist; Keith Batchelder, CEO of Genomic Healthcare Strategies in Charlestown, Mass.; Rosalynn Gill, founder of personalized health company Sciona in Aurora, Colo.; John Halamka, technology dean at Harvard Medical School; Stanley Lapidus, chairman and CEO of Helicos BioSciences Corp.

October 21, 2008 — Susannah F. Locke

Genome-Based Medical Choices Draw Nearer

A study of over 38,000 hypertension patients (the ALLHAT study, for Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial) finds that individuals respond better to some drugs than to others, based on their personal genetics. Steve Mirsky reports.

January 23, 2008

Genomes for All

Next-generation technologies that make reading DNA fast, cheap and widely accessible are coming in less than a decade. Their potential to revolutionize research and bring about the era of truly personalized medicine means the time to start preparing is now

January 1, 2006 — George M. Church

SNPs of Disease

The U.K. plans a national genomic database to study late-onset sickness

June 1, 2000 — Arlene Judith Klotzko

Facing Your Genetic Destiny

The use of predictive genetic tests is still limited to a handful of relatively rare and highly hereditary diseases, but that's about to change

February 18, 2002 — Sergio Pistoi

Starting Thanksgiving

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