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If you have heard about nanotechnology at all, you may be aware of its science-fiction-sounding hype. Proponents picture a future in which tiny bots would magically repair tissue to prolong our life span. On the dark side is the disturbing vision of “gray goo,” where self-replicating nanodevices destroy the planet. The reality of the burgeoning field of nanotech, however, is hardly less startling in its transformative potential. Some have proclaimed it “the next industrial revolution.”

“Nanotechnology” broadly applies to control of materials and components only a few billionths of a meter in size. Already manufacturers sell several hundred products that use nanotech, mainly skin lotions. Next up are advances in biotechnology and electronics—and a merging of the two.

Consider, for instance, molecular building blocks called bis-amino acids, which chemists string together into protein-like structures. Applications include medicines, enzymes for catalyzing reactions, sensors, nanoscale valves and computer storage devices. Other researchers are using natural molecular machines to process information: they receive input from other biological molecules and output a tangible result, such as a signal or a therapeutic drug.

Nanoscience advances are pushing traditional electronics in new directions as well. George Gruner describes applications that encompass sensors, solar cells, electronic paper and bendable touch screens. Imagine a morning “paper” with headlines that change as news breaks.

Or how about an invisibility cloak? Harry A. Atwater explains how optical signals squeeze through minuscule wires, producing so-called plasmons. Plasmonic circuits could help to move lots of data and improve the resolution of microscopes, the efficiency of light-emitting diodes, and the sensitivity of detectors. Such materials could alter the electromagnetic field around an object to such an extent that it would become invisible. The nanoregime offers enormous promise indeed.

BUILDING BLOCKS
Plenty of Room Indeed by Michael Roukes
There is plenty of room for practical innovation at the nanoscale. But first, scientists have to understand the unique physics that governs matter there

The Art of Building Small by George M. Whitesides and J. Christopher Love
Researchers are discovering cheap, efficient ways to make structures only a few billionths of a meter in size

Molecular Lego by Christian E. Schafmeister
A modest collection of small molecular building blocks enables the design and manufacture of nanometer-scale structures programmed to have virtually any shape desired

LIVING MACHINES
Nanotechnology and the Double Helix by Nadrian C. Seeman
DNA is more than just the secret of life—it is also a versatile component for making nanoscopic structures and devices

Bringing DNA Computers to Life by Ehud Shapiro and Yaakov Benenson
Tapping the computing power of biological molecules gives rise to tiny machines that can speak directly to living cells

THE SMALLEST CIRCUITS
Carbon Nanonets Spark New Electronics by George Gruner
Random networks of tiny carbon tubes could make possible low-cost, flexible devices such as “electronic paper” and printable solar cells

The Promise of Plasmonics by Harry A. Atwater
A technology that squeezes electromagnetic waves into minuscule structures may yield a new generation of superfast computer chips and ultrasensitive molecular detectors

The Incredible Shrinking Circuit by Charles M. Lieber
Researchers have built nanotransistors and nanowires. Now they just need to find a way to put them all together

FANTASTIC VOYAGE
Less Is More in Medicine by A. Paul Alivisatos
Sophisticated forms of nanotechnology will find some of their first real-world applications in ­biomedical research, disease diagnosis and, ­possibly, therapy

Shamans of Small by Graham P. Collins
Like interstellar travel, time machines and cyberspace, nanotechnology has become one of the core plot devices on which science-fiction writers draw