The attacks began in her early 20s; for two years now Stephanie* has been living under the pall of migraine. It usually starts with a visual disturbance called an aura—shimmering zigzag lines that move across her field of vision and gradually expand into blackness, blotting out her sight. Then comes pounding pain mainly on the left side of her head. Adding to her misery is an exquisite sensitivity to light, sound and smell that makes ordinary stimuli—even perfume—unbearable and the headache even worse.