The odds are high that humans will warm Earth’s climate to worrisome levels during the coming century. Although fossil-fuel combustion has generated most of the buildup of atmospheric carbon dioxide (CO2), effective solutions will require more than developing cleaner energy sources and hoping for their wide adoption. Equally important will be establishing institutions and strategies—particularly markets, business regulations and government policies—that will provide incentives for companies to apply innovative technologies and practices that reduce emissions of CO2 and other climate-altering greenhouse gases.