No one expects to live a before-and-after kind of life, divided into the moments before and the moments after a single defining event. When the two of us met, fell in love and got married in Sonia’s backyard in Hermitage, Pa., we had no idea we were in our “before” life. We had no intention of quitting our careers in law and engineering and taking entry-level jobs in a different field. We could not have imagined the scramble to learn an entirely new discipline from scratch nor a day when we would defend back-to-back our doctoral theses in biomedical research—our presentations intercalating to form a vision for a first-ever treatment for a fatal neurodegenerative disease.