By joining EyeWire, citizen scientists can help map the connectome, starting with connections between retinal neurons. EyeWire gameplay advances neuroscience by helping researchers discover how neurons connect and network to process information. Citizen scientists also help the EyeWire team develop advanced artificial intelligence and computational technologies for mapping the connectome.

In EyeWire, players are challenged to map branches of a neuron from one side of a cube to the other, like a 3-D puzzle. Players scroll through the cube (measuring about 4.5 microns per side or ~10x smaller than the average width of a human hair) and reconstruct neurons in volumetric segments with the help of an artificial intelligence algorithm developed specifically for the project. The project will also test whether citizen science can impact neuroscience in the same way that it has impacted fields like astronomy and biology.

No specialized knowledge of neuroscience is required; citizen scientists need only be curious, intelligent and observant. Engineers will use this input to improve the underlying computational technology, eventually making it powerful enough to detect "miswirings" of the brain that are hypothesized to underlie disorders like autism and schizophrenia. The researchers encourage citizen scientists to subscribe to their blog and connect with them on Facebook to get the latest EyeWire news.