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AIDS in 1988

In their first collaborative article the investigators who discovered HIV introduce a single-topic issue on AIDS. They recount the discovery and offer prospects for vaccine, for therapy and for the epidemic

By Luc Montagnier and Robert C. Gallo

The Molecular Biology of the AIDS Virus

HIV is genetically complex. An array of regulatory genes enables it to remain latent or replicate at various rates. This intricate control may underlie key features of the disease

By Flossie Wong-Staal and William A. Haseltine

The Origins of the AIDS Virus

The AIDS virus is not unique. It has relatives in man as well as other primates. Studies of related viruses indicate that some have evolved disease-free coexistence with their animal hosts

By Max Essex and Phyllis J. Kanki

The Epidemiology of AIDS in the U.S.

In 1981 Federal officials noted that a rarely prescribed drug was being dispensed more often. It was the first sign of the AIDS epidemic. By 1992 there will probably be 365,000 cases in the U.S.

By James W. Curran and William L. Heyward

The International Epidemiology of AIDS

Reports to the World Health Organization suggest that at least five million people worldwide are infected by the AIDS virus and a million new cases of AIDS are likely within the next five years

By James Chin, Jonathan M. Mann, Peter Piot and Thomas Quinn

HIV Infection: The Cellular Picture

A key finding of AIDS research is that infection begins when HIV binds to a molecule called CD4 on the target cell. Knowledge of that interaction may help in developing therapies or vaccines

By Jonathan N. Weber and Robin A. Weiss

AIDS Therapies

One drug-AZT-is already in clinical use. New knowledge of HIV makes it possible to design drugs that interrupt specific phases of the viral life cycle. More effective therapies are on the way

By Hiroaki Mitsuya, Robert Yarchoan and Samuel Broder

AIDS Vaccines

Several candidates are being tested and more are on the way, but success is far from assured. The life cycle of the virus and the logistics of AIDS vaccine testing make HIVa foe without precedent

By Dani P. Bolognesi and Thomas J. Matthews

The Social Dimensions of AIDS

AIDS exposes the hidden weaknesses in human society; how the epidemic is dealt with will have a profound effect on society's future. A crucial issue is protection from discrimination

By Harvey V. Fineberg

Departments

  • 50 and 100 Years Ago

  • AIDS and the Election

  • Starshower

  • Test-Ban Countdown

  • Weighty Matters

  • God Takes a Nap

  • Pacific Sea-saw

  • More Setbacks at SLAC

  • Planetary Consommé

  • Postprandial Warmth

  • Yeast Meets Est(rogen)

  • Maternal Dysinheritance

  • Bypass Blues

  • Making Bones Better

  • The Bionic Mind

  • HIV Infection: The Clinical Picture

  • Long March to Approval

  • Mega Projects

  • Signing Off?

  • Smart Apples

  • AIDS: An unknown distance still to go

  • Letters

    Letters to the Editors, October 1988

  • Recommended

    Books, October 1988

  • Amateur Scientist

    The Amateur Scientist, October 1989

  • Departments

    Computer Recreations, October 1988

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October 1988

See the World from a Different Perspective

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