AIDS in 1988
In their first collaborative article the investigators who discovered HIV introduce a single-topic issue on AIDS. They recount the discovery and offer prospects for vaccine, for therapy and for the epidemic...
Features
The Molecular Biology of the AIDS Virus
HIV is genetically complex. An array of regulatory genes enables it to remain latent or replicate at various rates. This intricate control may underlie key features of the disease
The Origins of the AIDS Virus
The AIDS virus is not unique. It has relatives in man as well as other primates. Studies of related viruses indicate that some have evolved disease-free coexistence with their animal hosts...
The Epidemiology of AIDS in the U.S.
In 1981 Federal officials noted that a rarely prescribed drug was being dispensed more often. It was the first sign of the AIDS epidemic. By 1992 there will probably be 365,000 cases in the U.S...
The International Epidemiology of AIDS
Reports to the World Health Organization suggest that at least five million people worldwide are infected by the AIDS virus and a million new cases of AIDS are likely within the next five years...
HIV Infection: The Clinical Picture
The human immunodeficiency virus causes a spectrum of disease that culminates in AIDS. Early detection of HIV infection, often years before symptoms emerge, is key to prolonging health and life...
HIV Infection: The Cellular Picture
A key finding of AIDS research is that infection begins when HIV binds to a molecule called CD4 on the target cell. Knowledge of that interaction may help in developing therapies or vaccines...
AIDS Therapies
One drug-AZT-is already in clinical use. New knowledge of HIV makes it possible to design drugs that interrupt specific phases of the viral life cycle. More effective therapies are on the way...
AIDS Vaccines
Several candidates are being tested and more are on the way, but success is far from assured. The life cycle of the virus and the logistics of AIDS vaccine testing make HIVa foe without precedent...
The Social Dimensions of AIDS
AIDS exposes the hidden weaknesses in human society; how the epidemic is dealt with will have a profound effect on society's future. A crucial issue is protection from discrimination
Departments
50 and 100 Years Ago
AIDS and the Election
Test-Ban Countdown
Starshower
Weighty Matters
Pacific Sea-saw
God Takes a Nap
More Setbacks at SLAC
Planetary Consommé
Postprandial Warmth
Yeast Meets Est(rogen)
Maternal Dysinheritance
Making Bones Better
Bypass Blues
The Bionic Mind
Long March to Approval
Signing Off?
Mega Projects
Smart Apples
AIDS: An unknown distance still to go
- Letters
Letters to the Editors, October 1988
- Recommended
Books, October 1988
- Amateur Scientist
The Amateur Scientist, October 1989
- Departments
Computer Recreations, October 1988
