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Life, Death and the Immune System

By defining and defending the self, the immune system makes life possible; malfunction causes illness and death. Study of the system provides a unifying view of biology

By Gustav J. V. Nossal

How the Immune System Develops

Environmental and genetic signals cue cells as they differentiate into the many lineages that recognize foreign antigens and fight off invaders

By Irving L. Weissman and Max D. Cooper

How the Immune System Recognizes Invaders

Cells of the immune system recombine gene fragments to create the millions of receptors needed to identify and attack the myriad pathogens encountered throughout life

By Charles A. Janeway

How the Immune System Recognizes the Body

The human immune system has developed several elegant processes that allow it to repel foreign invaders and yet not attack the body itself

By John W. Kappler and Philippa Marrack

Infectious Diseases and the Immune System

When bacteria, viruses and other pathogens infect the body, they hide in different places. Each component of the immune system is most adept at rousting trespassers from one location...

By William E. Paul

AIDS and the Immune System

The AIDS virus exploits the immune system to replicate itself. New findings are showing how it wreaks havoc on the body's defenses

By Warner C. Greene

Autoimmune Disease

Misguided assaults on the self produce multiple sclerosis, juvenile diabetes and other chronic illnesses. Promising therapies are emerging

By Lawrence Steinman

Allergy and the Immune System

In allergic individuals, parts of the immune system misdirect their power at innocuous substances, producing sometimes deadly symptoms

By Lawrence M. Lichtenstein

The Immune System as a Therapeutic Agent

New technologies and insights into the molecular underpinnings of the immune system provide the basis for novel approaches to vaccines and other therapies

By Hans Wigzell

Will we Survive?

As host and pathogen evolve together, will the immune system retain the upper hand?

By Avrion Mitchison


  • Letters

    Letters to the Editors, September 1993

  • Recommended

    Monticello Redux

  • 50, 100 & 150 Years Ago

    50 and 100 Years Ago: High-Frequency Heating and Questions About Evolution

  • Mathematical Recreation

    A Shepherd Takes a Sheep Shot

  • Science and the Citizen

    Super Trouble

  • Shaking Conventional Wisdom

  • Jovian Jolt

  • Fermat's MacGuffin

  • Malignant Mimicry

  • Fads and Feds

  • The All-Star of Buckyball

  • Departments

    The Greening of Garbage

  • Immunology and Reciprocity

  • Technology and Business

    Crystal Light

  • Contented Cows?

  • Très Grande Alliance

  • In Vitro, in the Money

  • Natural Selection

  • Blackballing the Inner City

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